相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。mTORC1 Activation Blocks BrafV600E-Induced Growth Arrest but Is Insufficient for Melanoma Formation
William Damsky et al.
CANCER CELL (2015)
Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
Carlos T. Pineda et al.
CELL (2015)
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Sylvia F. Boj et al.
CELL (2015)
Bridging Tumor Genomics to Patient Outcomes Through an Integrated Patient-Derived Xenograft Platform
David R. Gandara et al.
Clinical Lung Cancer (2015)
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
Christine M. Fillmore et al.
NATURE (2015)
Salt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer
Helene Bon et al.
MOLECULAR CANCER RESEARCH (2015)
Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression
Chunxiao Xu et al.
CANCER CELL (2014)
LKB1 inactivation sensitizes non-small cell lung cancer to pharmacological aggravation of ER stress
Landon J. Inge et al.
CANCER LETTERS (2014)
A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
Hailing Cheng et al.
CANCER RESEARCH (2014)
Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: Correlation with Jab1 stability and PI3K/Akt pathway
Hua Wang et al.
EXPERIMENTAL AND MOLECULAR PATHOLOGY (2014)
LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT
Jacob M. Kaufman et al.
JOURNAL OF THORACIC ONCOLOGY (2014)
Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway
Tao Du et al.
MOLECULAR CANCER (2014)
An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential
Jonathan M. Goodwin et al.
MOLECULAR CELL (2014)
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway
Morvarid Mohseni et al.
NATURE CELL BIOLOGY (2014)
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
Xingnan Li et al.
NATURE MEDICINE (2014)
Salt-Inducible Kinase 1 (SIK1) Is Induced by Gastrin and Inhibits Migration of Gastric Adenocarcinoma Cells
Linn-Karina M. Selvik et al.
PLOS ONE (2014)
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
Gregory R. Hoffman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death
H. Chen et al.
CELL DEATH & DISEASE (2014)
Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia
Houda Alachkar et al.
ONCOTARGET (2014)
Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss
Rafaela Andrade-Vieira et al.
ONCOTARGET (2014)
Imaging preclinical tumour models: improving translational power
Marion de Jong et al.
NATURE REVIEWS CANCER (2014)
LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
David B. Shackelford et al.
CANCER CELL (2013)
Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer
Hyun Seok Kim et al.
CELL (2013)
ARK5 promotes glioma cell invasion, and its elevated expression is correlated with poor clinical outcome
Shijun Lu et al.
EUROPEAN JOURNAL OF CANCER (2013)
LKB1 Represses Focal Adhesion Kinase (FAK) Signaling via a FAK-LKB1 Complex to Regulate FAK Site Maturation and Directional Persistence
Erik R. Kline et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer
Ruprecht Kuner et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2013)
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Jonathan M. Ostrem et al.
NATURE (2013)
A new model and modulator of pulmonary oedema
Charlotte Harrison
NATURE REVIEWS DRUG DISCOVERY (2013)
The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues
Yuji Nakada et al.
PLOS ONE (2013)
Incidence and risk of treatment-related mortality in cancer patients treated with EGFR-TKIs: A meta-analysis of 22 phase III randomized controlled trials
Wei-Xiang Qi et al.
RESPIRATORY MEDICINE (2013)
Overexpression of ARK5 is associated with poor prognosis in hepatocellular carcinoma
Jing Cui et al.
TUMOR BIOLOGY (2013)
Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer
Yan Liu et al.
CANCER DISCOVERY (2013)
Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors
Anne M. Strohecker et al.
CANCER DISCOVERY (2013)
LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma
Wenjin Liu et al.
CANCER CELL (2012)
Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis
Wen Cai Zhang et al.
CELL (2012)
Mortality After Incident Cancer in People With and Without Type 2 Diabetes Impact of metformin on survival
Craig J. Currie et al.
DIABETES CARE (2012)
Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin
Amy K. Rines et al.
FASEB JOURNAL (2012)
Metformin in cancer: translational challenges
Ryan J. O. Dowling et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2012)
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
Zhao Chen et al.
NATURE (2012)
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Jordi Barretina et al.
NATURE (2012)
Deregulated MYC expression induces dependence upon AMPK-related kinase 5
Lidan Liu et al.
NATURE (2012)
AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer
Suzanne L. Topalian et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation
Matthew D. Wilkerson et al.
PLOS ONE (2012)
Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1
Pradeep S. Tanwar et al.
PLOS GENETICS (2012)
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
Eric D. Segal et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
Jessie Yanxiang Guo et al.
GENES & DEVELOPMENT (2011)
LOCALIZATION-SPECIFIC LKB1 LOSS IN HEAD AND NECK SQUAMOUS CELL CARCINOMA METASTASIS
Erik R. Kline et al.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2011)
LKB1 Mutations Frequently Detected in Mucinous Bronchioloalveolar Carcinoma
Atsushi Osoegawa et al.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2011)
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
Seth A. Wander et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Structure of mammalian AMPK and its regulation by ADP
Bing Xiao et al.
NATURE (2011)
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Maria M. Mihaylova et al.
NATURE CELL BIOLOGY (2011)
Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis
Francis X. McCormack et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
C. Algire et al.
ONCOGENE (2011)
Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis
Catherine Emmanuel et al.
PLOS ONE (2011)
Lkb1 and Pten Synergise to Suppress mTOR-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder
Boris Y. Shorning et al.
PLOS ONE (2011)
AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma
Takeshi Namiki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan et al.
SCIENCE (2011)
AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
Jonathan S. Oakhill et al.
SCIENCE (2011)
AMP-activated protein kinase: also regulated by ADP?
D. Grahame Hardie et al.
TRENDS IN BIOCHEMICAL SCIENCES (2011)
The tumor suppressor kinase LKB1: lessons from mouse models
Saara Ollila et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2011)
mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
Vanessa S. Rodrik-Outmezguine et al.
CANCER DISCOVERY (2011)
The APL Paradigm and the Co-Clinical Trial Project
Caterina Nardella et al.
CANCER DISCOVERY (2011)
Proposal for dosage adjustment and timing of chemotherapy in hemodialyzed patients
N. Janus et al.
ANNALS OF ONCOLOGY (2010)
Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
Julian Carretero et al.
CANCER CELL (2010)
SIK2 Is a Centrosome Kinase Required for Bipolar Mitotic Spindle Formation that Provides a Potential Target for Therapy in Ovarian Cancer
Ahmed Ashour Ahmed et al.
CANCER CELL (2010)
Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
Michael Pollak
CANCER PREVENTION RESEARCH (2010)
Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
Simon A. Hawley et al.
CELL METABOLISM (2010)
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
Cristina M. Contreras et al.
DISEASE MODELS & MECHANISMS (2010)
Lactic Acidosis Induced by Metformin Incidence, Management and Prevention
Jean-Daniel Lalau
DRUG SAFETY (2010)
Growth and Invasion of Sporadic Colorectal Adenocarcinomas in Terms of Genetic Change
Seon Ae Roh et al.
JOURNAL OF KOREAN MEDICAL SCIENCE (2010)
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Daisuke Nakada et al.
NATURE (2010)
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
Sushma Gurumurthy et al.
NATURE (2010)
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
Boyi Gan et al.
NATURE (2010)
TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity
M-C Liang et al.
ONCOGENE (2010)
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
Yijun Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Sunitinib Prolongs Survival in Genetically Engineered Mouse Models of Multistep Lung Carcinogenesis
Leena Gandhi et al.
CANCER PREVENTION RESEARCH (2009)
Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation
Bin Zheng et al.
MOLECULAR CELL (2009)
Somatic LKB1 Mutations Promote Cervical Cancer Progression
Shana N. Wingo et al.
PLOS ONE (2009)
mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
David B. Shackelford et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis
Hailing Cheng et al.
SCIENCE SIGNALING (2009)
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
Morris E. Feldman et al.
PLOS BIOLOGY (2009)
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford et al.
NATURE REVIEWS CANCER (2009)
Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer
Mark R. Pickard et al.
BREAST CANCER RESEARCH (2009)
Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling
Chongjuan Wei et al.
CLINICAL CANCER RESEARCH (2008)
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
Pedro P. Medina et al.
HUMAN MUTATION (2008)
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Sauveur-Michel Maira et al.
MOLECULAR CANCER THERAPEUTICS (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding et al.
NATURE (2008)
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Beth Apsel et al.
NATURE CHEMICAL BIOLOGY (2008)
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
Pekka Katajisto et al.
NATURE GENETICS (2008)
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Jeffrey A. Engelman et al.
NATURE MEDICINE (2008)
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
John J. Bissler et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
James A. Dykens et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome
M. Sanchez-Cespedes
ONCOGENE (2007)
LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji et al.
NATURE (2007)
Phonformin-induced lactic acidosis in an older diabetic patient
FL Fimognari et al.
DIABETES CARE (2006)
Increased cancer-related mortality for patients with type 2 diabetes who use sulforrylureas or insulin
SL Bowker et al.
DIABETES CARE (2006)
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
KE O'Reilly et al.
CANCER RESEARCH (2006)
ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma
A Suzuki et al.
ONCOGENE (2005)
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
RL Hurley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
VN Anisimov et al.
EXPERIMENTAL GERONTOLOGY (2005)
Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
A Woods et al.
CELL METABOLISM (2005)
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
SA Hawley et al.
CELL METABOLISM (2005)
Metformin and reduced risk of cancer in diabetic patients
JMM Evans et al.
BMJ-BRITISH MEDICAL JOURNAL (2005)
ARK5 is a tumor invasion-associated factor downstream of Akt signaling
A Suzuki et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
ARK5 expression in colorectal cancer and its implications for tumor progression
G Kusakai et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw et al.
CANCER CELL (2004)
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
MN Corradetti et al.
GENES & DEVELOPMENT (2004)
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations
P Fernandez et al.
ONCOGENE (2004)
Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene
J Carretero et al.
ONCOGENE (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
A Woods et al.
CURRENT BIOLOGY (2003)
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
SP Hong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
DJ Rossi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
N Bardeesy et al.
NATURE (2002)
Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3
M Hayer-Zillgen et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
K Jishage et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
A Ylikorkala et al.
SCIENCE (2001)
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the philadelphia chromosome.
BJ Druker et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Prevention of pancreatic cancer induction in hamsters by metformin
MB Schneider et al.
GASTROENTEROLOGY (2001)
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
MR Owen et al.
BIOCHEMICAL JOURNAL (2000)
分享论文
