期刊
MEDICINAL CHEMISTRY RESEARCH
卷 30, 期 10, 页码 1795-1821出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-021-02779-6
关键词
Natural products; Oridonin; Structural modification; Anticancer activity; Drug resistance
资金
- National Natural Sciences Foundations of China [81703541, U2004123, 81673322]
- China Postdoctoral Science Foundation [2018M632812]
- Henan Association of Science and Technology [2020HYTP056]
- Science and Technology Department of Henan Province [20202310144]
- state key laboratory of Pharmaceutical Biotechnology, Nan-jing University, China [KF-GN-202101]
Oridonin, derived from traditional Chinese medicine Isodon rubescens, shows various biological functions such as anticancer, anti-inflammation, and antibacterial properties. Despite multiple anticancer mechanisms, its poor pharmaceutical properties have hindered its clinical research and application. Researchers are working to improve oridonin's pharmaceutical properties for potential anticancer use.
Numerous antitumor drugs exhibited excellent anti-proliferation activities, discovered from natural products. Oridonin is isolated from a traditional Chinese medicine Isodon rubescens, and it exhibit various biological functions including anticancer, anti-inflammation, antibacterial, and so on. The anticancer mechanisms of oridonin include apoptosis, autophagy, cell cycle arrest, and so on. However, clinical research and application of oridonin has been hampered, due to the poor pharmaceutical property. So many studies on oridonin have been explored in the purpose of improve the pharmaceutical property, including investigation of the mechanism of action in depth and structural modification. In this review, we summarized oridonin and oridonin derivatives as potential anticancer agents, and detailed discussion on biological properties, mechanism of actions and potential for overcoming therapeutic resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据