4.4 Article

Encefalitis como manifestacion neurologica del COVID-19

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MEDICINA CLINICA
卷 157, 期 3, 页码 141-143

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ELSEVIER ESPANA SLU
DOI: 10.1016/j.medcli.2021.03.008

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Encephalitis; SARS-CoV-2; COVID-19; Neurology; Neurological manifestations

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In the context of the global COVID-19 pandemic, respiratory symptoms caused by infection may overshadow neurological manifestations, leading to delayed diagnosis and treatment. Two cases of COVID-19 patients presenting with encephalitis symptoms were reported, highlighting the lack of specific treatment options for this condition.
Introduction: In the context of the global COVID-19 pandemic, the different clinical manifestations of this infection pose a challenge for healthcare professionals. Respiratory involvement, the main symptom of SARS-CoV-2 infection, means that other manifestations, such as neurological, take a back seat, with the consequent delay in diagnosis and treatment. Material and methods: All COVID-19 patients admitted with neurological symptoms or diagnosed with encephalitis since March 2020 in a tertiary hospital in Zaragoza, Spain. Results: Two patients with COVID-19 infection confirmed by nasopharyngeal PCR and whose clinical picture consisted of neurological alterations compatible with encephalitis. Cerebrospinal fluid (CSF) microbiology was negative for bacteria and viruses, including SARS-CoV-2 but, given the clinical suspicion of encephalitis due to the latter, antiviral treatment with immunoglobulins and plasmapheresis was started early. Despite this, the evolution was not satisfactory. Conclusions: COVID-19 encephalitis is a recently described clinical entity, whose pathophysiology is still unknown and no treatment with clinical evidence is available to date. (c) 2021 Elsevier Espana, S.L.U. All rights reserved.

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