FLASH radiotherapy with carbon ion beams

FLASH radiotherapy is considered a new potential breakthrough in cancer treatment. Ultra-high dose rates (>40 Gy/s) have been shown to reduce toxicity in the normal tissue without compromising tumor control, resulting in a widened therapeutic window. These high dose rates are more easily achievable in the clinic with charged particles, and clinical trials are, indeed, ongoing using electrons or protons. FLASH could be an attractive solution also for heavier ions such as carbon and could even enhance the therapeutic window. However, it is not yet known whether the FLASH effect will be the same as for sparsely ionizing radiation when densely ionizing carbons ions are used. Here we discuss the technical challenges in beam delivery and present a promising solution using 3D range-modulators in order to apply ultra-high dose rates (UHDR) compatible with FLASH with carbon ions. Furthermore, we will discuss the possible outcome of C-ion therapy at UHDR on the level of the radiobiological and radiation chemical effects.

Automated summary

FLASH radiotherapy is a potential breakthrough in cancer treatment, utilizing ultra-high dose rates to reduce normal tissue toxicity while maintaining tumor control. There are ongoing clinical trials exploring the use of charged particles such as electrons or protons, with promising outcomes. However, technical challenges remain, particularly in determining the effectiveness of FLASH therapy with heavier ions like carbon.