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Vaccination of cancer patients against COVID-19: towards the end of a dilemma

MEDICAL ONCOLOGY (2021)

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Letter Virology

Cancer prevales on COVID-19: To maintain high quality standard concerning diagnosis and oncological care even during a pandemic

Jacopo Giuliani et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Oncology

Prevalence and Clinical Impact of SARS-CoV-2 Silent Carriers Among Actively Treated Patients with Cancer During the COVID-19 Pandemic

Alberto Zambelli et al.

Summary: The study tested 560 asymptomatic cancer patients receiving anticancer treatment and found that 31% of the patients tested positive for anti-SARS-CoV-2 immunoglobulin. In a second screening, 38% of the patients were identified as silent carriers of SARS-CoV-2. Among the silent carriers who continued anticancer treatment, only one developed symptomatic COVID-19.

ONCOLOGIST (2021)

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Article Oncology

Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited

Antoni Ribas et al.

Summary: Patients with cancer, especially those with hematologic malignancies, are considered among the very high-risk groups for priority COVID-19 vaccination due to the confluence of risk factors between cancer and the virus, which may increase exposure and suppress immune responses.

CANCER DISCOVERY (2021)

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Article Hematology

Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study

Akshay Sharma et al.

Summary: This study examined the characteristics and outcomes of HSCT recipients after developing COVID-19. It found that recipients of autologous and allogeneic HSCT who develop COVID-19 have poor overall survival rates. Factors such as age, sex, and time since transplantation were associated with higher risk of mortality in HSCT recipients.

LANCET HAEMATOLOGY (2021)

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Editorial Material Oncology

The ESMO Call to Action on COVID-19 vaccinations and patients with cancer: Vaccinate. Monitor. Educate

M. C. Garassino et al.

ANNALS OF ONCOLOGY (2021)

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Editorial Material Oncology

The effect of COVID-19 pandemic on daily oncology clinical practice Comment

Giovanni Codacci-Pisanelli et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

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Editorial Material Medicine, General & Internal

Choices in a Crisis - Individual Preferences among SARS-CoV-2 Vaccines

Daniel B. Kramer et al.

Summary: With increasing experience with SARS-CoV-2 vaccination, differences among vaccines may become more apparent, leading to discussions on whether individuals should be able to choose which vaccine they receive.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Editorial Material Oncology

Short-term safety of the BNT162b2 mRNA COVID-19 vaccine in patients with cancer treated with immune checkpoint inhibitors

Barliz Waissengrin et al.

LANCET ONCOLOGY (2021)

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Article Oncology

COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials

Aakash Desai et al.

Summary: The rapid development of COVID-19 vaccines has provided new hope of mitigating the disease, and it is necessary to prioritize cancer patients, including those participating in oncology clinical trials, for vaccination. Data on the safety, tolerability and efficacy of the vaccines in patients with cancer are currently limited, but the benefits of vaccination are likely to far outweigh the risks of adverse events.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Oncology

Factors associated with SARS-CoV-2 infection and outcome in patients with solid tumors or hematological malignancies: a single-center study

Anouk Goudsmit et al.

Summary: In patients referred for SARS-CoV-2 testing, hematological malignancies were associated with a higher risk of COVID-19 infection and severe outcomes. Other factors were age and inpatient status.

SUPPORTIVE CARE IN CANCER (2021)

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Review Oncology

Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel mechanistic considerations

Edward J. Calabrese et al.

Summary: Low-dose radiotherapy can induce antioxidant responses via Nrf2 activation, which helps alleviate inflammation in COVID-19 patients and prevent mortality. It is suggested to administer this treatment before cytokine storms occur in order to achieve optimal outcomes.

RADIOTHERAPY AND ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection

Pablo Fuentes-Prior

Summary: The COVID-19 pandemic has caused over a million deaths worldwide, and the death toll is expected to rise further before effective treatments and vaccines are available. The causative agent, SARS-CoV2, has significant differences from the previous SARS-CoV-1 and has a higher transmission rate, affecting multiple organs in addition to the lungs. Understanding the role of membrane-associated serine proteinases (MASPs) in the activation of the virus spike protein could potentially help in controlling the pandemic.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Oncology

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N=4532)

M. Montopoli et al.

ANNALS OF ONCOLOGY (2020)

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Letter Oncology

Lower detection rates of SARS-COV2 antibodies in cancer patients versus health care workers after symptomatic COVID-19

M. L. Solodky et al.

ANNALS OF ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Article Immunology

Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

Ling Ni et al.

IMMUNITY (2020)

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Letter Infectious Diseases

Clinical characteristics and prognosis in cancer patients with COVID-19: A single center's retrospective study

Jia Ma et al.

JOURNAL OF INFECTION (2020)

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Letter Infectious Diseases

Cancer in intensive care unit patients with COVID-19

Sergey Moiseev et al.

JOURNAL OF INFECTION (2020)

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Article Oncology

Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak

Mengyuan Dai et al.

CANCER DISCOVERY (2020)

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Article Oncology

Impact of PD-1 Blockade on Severity of COVID-19 in Patients with Lung Cancers

Jia Luo et al.

CANCER DISCOVERY (2020)

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Article Medicine, General & Internal

COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study

Lennard Y. W. Lee et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

Nicole M. Kuderer et al.

LANCET (2020)

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Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

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Article Oncology

High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR

Souad Assaad et al.

EUROPEAN JOURNAL OF CANCER (2020)

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Article Oncology

COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study

Marina Chiara Garassino et al.

LANCET ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Carolyn Rydyznski Moderbacher et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Determinants of COVID-19 disease severity in patients with cancer

Elizabeth V. Robilotti et al.

NATURE MEDICINE (2020)

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Review Hematology

Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients

Abi Vijenthira et al.

BLOOD (2020)

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Letter Medicine, General & Internal

Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer

Teresa Aydillo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Ania Wajnberg et al.

SCIENCE (2020)

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Article Oncology

Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost- effective anti-inflammatory treatment

Pedro C. Lara et al.

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY (2020)

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Review Oncology

The immuno-oncological challenge of COVID-19

Lisa Derosa et al.

NATURE CANCER (2020)

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Review Microbiology

Respiratory Viral Infections in Patients With Cancer or Undergoing Hematopoietic Cell Transplant

Diego R. Hijano et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Medicine, General & Internal

Adult haemophagocytic syndrome

Manuel Ramos-Casals et al.

LANCET (2014)

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Article Endocrinology & Metabolism

Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element

Liesbeth Clinckemalie et al.

MOLECULAR ENDOCRINOLOGY (2013)

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Review Biochemistry & Molecular Biology

Type II transmembrane serine proteases in cancer and viral infections

So-Young Choi et al.

TRENDS IN MOLECULAR MEDICINE (2009)

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