Histopathological changes of myocytes in restrictive cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare primary myocardial disease, and its pathological features are yet to be determined. Restrictive cardiomyopathy with MHY7 mutation was diagnosed in a 65-year-old Japanese woman. Electron microscopy of a myocardial biopsy revealed electron-dense materials resulting from focal myocyte degeneration and necrosis as well as tubular structures and pseudo-inclusion bodies in some nuclei. These features may be associated with the pathogenesis of RCM.

Automated summary

Restrictive cardiomyopathy is a rare primary myocardial disease with unclear pathological features. A 65-year-old Japanese woman was diagnosed with MHY7 mutation-related RCM, with electron microscopy of a myocardial biopsy revealing specific features possibly associated with the pathogenesis of the disease.