Entropy modulation of electroencephalographic signals in physiological aging

Aging is a multifactorial physiological process characterized by the accumulation of degenerative processes impacting on different brain functions, including the cognitive one. A tool largely employed in the investigation of brain networks is the electroencephalogram (EEG). Given the cerebral complexity and dynamism, many nonlinear approaches have been applied to explore age-related brain electrical activity modulation detected by the EEG: one of them is the entropy, which measures the disorder of a system. The present study had the aim to investigate aging influence on brain dynamics applying Approximate Entropy (ApEn) parameter to resting state EEG data of 68 healthy adult participants, divided with respect to their age in two groups, focusing on several specialized brain regions. Results showed that elderly participants present higher ApEn values than younger participants in the central, parietal and occipital areas, confirming the hypothesis that aging is characterized by an evolution of brain dynamics. Such findings may reflect a reduced synchronization of the neural networks cyclic activity, due to the reduction of cerebral connections typically found in aging process. Understanding the dynamics of brain networks by applying the entropy parameter could be useful for developing appropriate and personalized rehabilitation programs and for future studies on neurodegenerative diseases.

Automated summary

The study found that elderly participants showed higher levels of disorder in the central, parietal, and occipital brain regions compared to younger participants, indicating a decrease in neural network synchronization associated with the aging process. This reduced synchronization may be due to the decline in cerebral connections typically observed in aging, highlighting the importance of understanding brain dynamics using entropy parameters for developing personalized rehabilitation programs and future research on neurodegenerative diseases.