One step synthesis approach of mesoporous silica packed with graphene oxide nanosheet: Characterisation and drug release aspects

The motive of the present investigation was to establish a novel, hybrid multifunctional lipid-coated graphene oxide mesoporous silica nanocomposite (GO-MSN) for controlled delivery of Rizatriptan Benzoate (RiB). The lipid coating helps to achieve a longer circulation time of the fabricated carrier for targeted delivery of RiB. The modified Hummers method with slight modification gives a uniform sheet of GO, subsequently sol-gel approach use to synthesized mesoporous silica for the preparation of nanocomposite. The in-vitro RiB release from RiB-GO-MSN and lipid decorated GO-MSN was found to be 70.74% and 63.45% respectively. The lipid coating retards the release of RiB around 8 h. The entrapment efficiency of RiB-MSN and GO-MSN were found to be 48.17% and 62.29% respectively. In the presence of GO, RiB entrapment increases as RiB may entrap within inter and intra spacing of GO. The present investigation oversee, simple methodology adopted for synthesis of GO-MSN can effectively deliver RiB towards brain for the management of migraine.

Automated summary

The study established a novel lipid-coated graphene oxide mesoporous silica nanocomposite for controlled delivery of Rizatriptan Benzoate, showing improved entrapment efficiency compared to traditional mesoporous silica. The lipid coating contributed to prolonged circulation time and delayed release of the drug, demonstrating potential for targeted delivery towards brain for migraine management.