期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 42, 期 -, 页码 1-17出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2016.05.002
关键词
Maternal; Postpartum; Depression; Addiction; Reward; Social behavior; Mental health; MicroRNA; Oxytocin; Prolactin
资金
- United States National Institutes of Health [R01 MH 085642]
Changes in expression of hundreds of genes occur during the production and function of the maternal brain that support a wide range of processes. In this review, we synthesize findings from four microarray studies of different maternal brain regions and identify a core group of 700 maternal genes that show significant expression changes across multiple regions. With those maternal genes, we provide new insights into reward-related pathways (maternal bonding), postpartum depression, social behaviors, mental health disorders, and nervous system plasticity/developmental events. We also integrate the new genes into well-studied maternal signaling pathways, including those for prolactin, oxytocin/vasopressin, endogenous opioids, and steroid receptors (estradiol, progesterone, cortisol). A newer transcriptional regulation model for the maternal brain is provided that incorporates recent work on maternal microRNAs. We also compare the top 700 genes with other maternal gene expression studies. Together, we highlight new genes and new directions for studies on the postpartum brain. (C) 2016 Elsevier Inc. All rights reserved.
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