期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 40, 期 -, 页码 87-100出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2016.01.002
关键词
Estrogens; Hormone therapy; Inflammation; Neuroinflammation; Cognition; Dementia
资金
- Women's College Research Institute
- Enid Walker Estate
- Canadian Breast Cancer Foundation - Ontario Region
- Canadian Institute of Health Research
The effects of estrogens are pleiotropic, affecting multiple bodily systems. Changes from the body's natural fluctuating levels of estrogens, through surgical removal of the ovaries, natural menopause, or the administration of exogenous estrogens to menopausal women have been independently linked to an altered immune profile, and changes to cognitive processes. Here, we propose that inflammation may mediate the relationship between low levels of estrogens and cognitive decline. In order to determine what is known about this connection, we review the literature on the cognitive effects of decreased estrogens due to oophorectomy or natural menopause, decreased estrogens' role on inflammation - both peripherally and in the brain - and the relationship between inflammation and cognition. While this review demonstrates that much is unknown about the intersection between estrogens, cognition, inflammation, we propose that there is an important interaction between these literatures. Crown Copyright (C) 2016 Published by Elsevier Inc.
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