期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2021.112102
关键词
Hyaluronic acid; Injectable hydrogels; Drug delivery; Antibiotics; Acetylsalicylic acid; Staphylococcus aureus
资金
- Basque Government (FRONTIERS project, ELKARTEK program, HAZITEK program - IMABI) [ZE-2019/00012]
- Department of Development and Infrastructures of the Basque Country
- i+Med S. Coop.
- Basque Government [01-AF-W2-2018-00002]
Hyaluronic acid hydrogels crosslinked with divinyl sulfone and loaded with antibiotics exhibit biocompatibility and antibacterial properties, effectively combating Staphylococcus aureus infections and enhancing the antibacterial activity of commonly used antibiotics against S. aureus.
Hyaluronic acid (HA) solutions were crosslinked with divinyl sulfone (DVS) and subsequently loaded with antibiotic molecules to obtain biocompatible and antibacterial injectable hydrogels. The crosslinking degree of the hydrogels was modulated by varying the reaction time and the HA:DVS weight ratio. Synthesized HA-DVS hydrogels were characterized by their rheological properties, pore size, swelling capacity and hydrolytic and thermal degradation. Biocompatibility was assessed by measuring pH, osmolality and by in vitro cytotoxic assay. Acetyl salicylic (AAS) loaded hydrogels display anti-inflammatory properties in vitro, whereas cefuroxime (CFX), tetracycline (TCN) and amoxicillin (AMX) loaded hydrogels show in vitro antibacterial activity against Staphylococcus aureus. The combine use of antibiotics and AAS produces a synergic effect that reduces the S. aureus population up to a log10 reduction (R) of 5.55. Overall results show that antibiotic/AAS loaded HA-DVS hydrogels could be effectively used to combat S. aureus infections and to increase the antibacterial activity of antibiotics commonly used against S. aureus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据