期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2021.112129
关键词
Bone healing; Electrical stimulation; Piezoelectric; Scaffold; Selective laser sintering
资金
- Natural Science Foundation of China [51935014, 82072084, 81871498]
- Jiangxi Provincial Natural Science Foundation of China [20192ACB20005, 2020ACB214004, 20202BAB214011]
- The Provincial Key R AMP
- D Projects of Jiangxi [20201BBE51012]
- Guangdong Province Higher Vocational Colleges AMP
- Schools Pearl River Scholar Funded Scheme (2018)
- Science and Technology Project of Jiangxi Provincial Department of Education [GJJ180490, GJJ200801]
- Opening Project of State Key Laboratory of Polymer Materials Engineering (Sichuan University) [sklpme2020415]
- Innovation Team Project on University of Guangdong Province [2018GKCXTD001]
- Technology Innovation Platform Project of Shenzhen Institute of Information Technology [PT2020E002]
Piezoelectric composites incorporating BaTiO3@carbon (BT@C) hybrid nanoparticles show enhanced piezoelectric performance and mechanical properties, accelerating cell proliferation and differentiation. The carbon shell strengthens the local electric field loaded on BT and induces the formation of beta phase, enhancing the piezoelectric response of the scaffolds.
Piezoelectric composites have shown great potential in constructing electrical microenvironment for bone healing since their integration of polymer flexibility and ceramic piezoelectric coefficient. Herein, core-shell structured BaTiO3@carbon (BT@C) hybrid nanoparticles were prepared by in situ oxidative selfpolymerization and template carbonization. Then the BT@C was introduced into polyvinylidene fluoride (PVDF) scaffolds manufactured by selective laser sintering. On one hand, the carbon shell could strengthen the local electric field loaded on BT in poling process owing to it served as a diffusion layer to provide space for charge transfer and accumulation. In this case, more electric domain within BT would be aligned along the polarization field direction and thus promoted the paly of BT's piezoelectric activity. On the other hand, the carbon shell could induce the formation of beta phase due to the sp2 hybrid-bonded carbon atoms in carbon shell forming electrostatic interaction with hydrogen atoms in PVDF chains, which further enhanced the piezoelectric response of the scaffolds. Results showed that the scaffold presented augmented piezoelectric performance with output voltage of 5.7 V and current of 79.8 nA. The improved electrical signals effectively accelerated cell proliferation and differentiation. Furthermore, the scaffold displayed improved mechanical performance due to rigid particle strengthen effect.
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