期刊
MARINE POLLUTION BULLETIN
卷 168, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.marpolbul.2021.112393
关键词
Plasticizers; Mussels; Antioxidant; Metabolomics; Ecotoxicology
资金
- Natural Science Foundation of Zhejiang Province [LQ21D060003, LGF21C190001]
- National Natural Science Foundation of China [31772856]
- Ningbo Science and Technology of China [31772856]
- General Scientific Research Project of Department of Education of Zhejiang Province [Y201940917]
The study demonstrated that exposure to various concentrations of PAEs affected the antioxidant responses and metabolic balance of marine mussels, influencing amino acid metabolism, lipid metabolism, energy metabolism, osmoregulation, and nerve activities in the mussels. These findings provide further insight into the toxicological effects of PAEs on marine organisms.
In this study, marine mussels (Mytilus coruscus) were exposed to three typical PAEs (dimethyl phthalate [DMP], dibutyl phthalate [DBP] and di(2-ethylhexyl) phthalate [DEHP]) at a range of doses for different times to investigate the ecotoxicological effects. The accumulation of the three PAE congeners in M. coruscus exhibited the following trend: DEHP > DBP > DMP. The antioxidant response of mussel gonadal tissue was enhanced with increasing concentrations of PAEs. For the DBP and DEHP treatment groups, glutathione (GSH) worked in concert with antioxidant enzymes to protect cells against reactive oxygen species (ROS), while GSH played a prominent antioxidant role in the DMP-treated group. The metabolomics results revealed that PAE exposure disrupted the metabolic balance of mussels. Overall, PAEs affect the amino acid metabolism, lipid metabolism, energy metabolism, osmoregulation and nerve activities of mussels. Our results provide further insight into the toxicological effects of PAEs on marine organisms.
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