期刊
MARINE ENVIRONMENTAL RESEARCH
卷 169, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.marenvres.2021.105326
关键词
Anadara broughtonii; Hypoxia; Sulfide; Oxidative stress; Apoptosis
资金
- National Key RAMP
- D Program of China [2019YFD0901303]
- National Natural Science Foundation of China [32072966]
The study found that the ark shells displayed some degree of tolerance to hypoxia and sulfide exposure, but were susceptible to the effects of reoxygenation. Sulfide had a notable impact on reducing oxidative stress and lipid peroxide accumulation caused by reoxygenation. Additionally, exogenous sulfide showed biphasic effects on the apoptotic cascade.
Oxygen deficit and sulfide have been restrictive factors in mariculture zones. However, the adaptive mechanism in aquatic lives is still unclear. The commercial ark shells Anadara broughtonii were selected to test the tolerance and adaptive responses to prolonged and intermittent hypoxia with or without exogenous sulfide (mild, moderate, high) by evaluating their behavior, mortality, oxidative level, antioxidant responses, and the MAPKmediated apoptosis in gills. The results indicated that the clams were tolerant to hypoxia and sulfide exposure but vulnerable during reoxygenation from the challenges. Even so, sulfide had remarkable effect on attenuating the accumulation of reactive oxygen species (ROS) and lipid peroxides caused by reoxygenation from prolonged hypoxia. The increase of glutathione level was probably as an early and primary protective response to prevent the expected reperfusion injury from reoxygenation. The challenges suppressed the oxidative level with a dosedependent effect of sulfide, with an exception when exposed to mild sulfide. Synchronously, biphasic effects of exogenous sulfide on apoptotic cascade, which was induced by mild sulfide while it was inhibited by higher sulfide, were also detected in gills. The induced or inhibited apoptosis by hypoxia and sulfide kept to a typical ROS-MAPK-CASPASE cascade, desiderating further investigation.
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