期刊
MARINE DRUGS
卷 19, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/md19080433
关键词
Red Sea sponge; Pseudoceratina arabica; marine alkaloids; psammaplysin dimer; psammaceratin A; psammaplysin A; cell lines' growth inhibition
资金
- Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia [1014]
Bioassay-guided fractionation of extract from Red Sea sponge led to isolation of a novel dimer, psammaceratin A, and a known compound psammaplysin A, both showing significant growth inhibition activity against cancer cells.
Bioassay-guided partition of the extract of the Red Sea sponge Pseudoceratina arabica and HPLC purification of the active fraction gave a psammaplysin dimer, psammaceratin A (1), along with psammaplysin A (2). The dimer comprises two units of psammaplysin A (2) connected via the terminal amines with an unprecedented (2Z,3Z)-2,3-bis(aminomethylene)succinamide moiety, and it represents the first dimer to be identified among the psammaplysin family. Data from 1D- and 2D-NMR and HRMS supported the chemical structures of the compounds. Psammaceratin A (1) and psammaplysin A (2) exhibited significant growth inhibition of HCT 116, HeLa, and MBA-MB-231 cells down to 3.1 mu M.
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