期刊
MARINE DRUGS
卷 19, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/md19090505
关键词
Red Sea Verongiid sponge; Suberea mollis; marine-derived fungus; Fusarium sp; LY019; marine alkaloid dimers; fusaripyridines A and B; antimicrobial activity; C; albicans; cancer cell growth inhibition; HeLa cells
资金
- Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia [1317]
The fungal strain Fusarium sp. LY019 was isolated from the Red Sea sponge Suberea mollis, producing two novel dimeric alkaloids, fusaripyridines A and B. These compounds exhibit a unique molecular structure and antimicrobial activity, providing insights into the biosynthetic capabilities of marine-derived fungi.
The fungal strain, Fusarium sp. LY019, was obtained from the Red Sea sponge Suberea mollis. Bioassay-directed partition of the antimicrobial fraction of the extract of the culture of the fungus provided two dimeric alkaloids, fusaripyridines A and B (1 and 2). The compounds possess a previously unreported moiety, 1,4-bis(2-hydroxy-1,2-dihydropyridin-2-yl)butane-2,3-dione. Further, the compounds display a highly oxygenated substitution pattern on the dihydropyridine moieties, representing an additional feature of the fusaripyridines. Fusaripyridines A and B are the first examples of natural products possessing 1,4-bis(2-hydroxy-1,2-dihydropyridin-2-yl)butane-2,3-dione backbone. Careful analyses of the one- and two-dimensional NMR and HRESIMS spectra of the compounds secured their structural mapping, while their absolute stereochemistry was established by analyses of their ECD spectra. The production of such dimeric alkaloids with an unprecedented moiety in the culture of Fusarium sp. LY019 supports further understanding of the biosynthetic competences of the cultured marine-derived fungi. Fusaripyridines A and B selectively inhibited the growth of Candida albicans with MIC values down to 8.0 mu M, while they are moderately active against S. aureus, E. coli and HeLa cells.
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