期刊
MACROMOLECULES
卷 54, 期 16, 页码 7448-7459出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.1c01180
关键词
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资金
- National Natural Science Foundation of China [51874332]
- Shandong Provincial Natural Science Foundation, China [ZR2019MB023]
- Fundamental Research Funds for the Central Universities [YCX2019071]
The study shows that comb-like copolymers can self-assemble into onion-like vesicles via PISA, improving preparation efficiency and structural stability, and suitable for drug and gene delivery applications.
A multilamellar or onion-like vesicle is an enclosed structure always self-assembled by multiple polymer bilayers. Compared with the unilamellar vesicle, onion-like vesicles show more complex functionality and better structural stability, making onion-like vesicles have better and more applications in drug and gene delivery. On the other hand, polymerization-induced self-assembly (PISA) is an improved polymer self-assembly strategy that can significantly increase preparation efficiency. Therefore, using the PISA strategy to prepare onion-like vesicles can further increase their commercial application potential. Herein, we show computer evidence that comb-like copolymers can self-assemble into the onion-like vesicle by PISA. The influence of rigidity, degree of polymerization, and structural symmetry of the macromolecular chain transfer agent (macro-CTA) on the morphology transformation is explored in our work. At the same time, we find the hollow onion-like vesicle and the solid onion-like vesicle can be synthesized by regulating the structural symmetry of macro-CTA, and the formation ways are different. Finally, we develop design guidelines of comb-like copolymers for preparing the onion-like vesicle by PISA, which can be exploited for drug and gene delivery applications.
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