期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 222, 期 19, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.202100212
关键词
amphiphiles; dendrimers; self-assembly
资金
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [2017R1D1A1B03029073]
- National Research Foundation of Korea [2017R1D1A1B03029073] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The synthesis of stimuli-responsive amphiphilic dendrimers composed of hydrophobic octadecyl groups linked to hydrophilic polylysine dendrons through disulfide linkage is reported. These dendrimers can form spherical micelles that disassemble in the presence of glutathione, serving as key building blocks for generating stimuli-responsive supramolecular architectures.
The synthesis of stimuli-responsive amphiphilic dendrimers consisting of two or three hydrophobic octadecyl groups linked to either a second or third generation hydrophilic polylysine dendron through disulfide linkage is reported. The polylysine dendrimers functionalized with four or eight tert-butyloxycarbonyl (Boc)-protected amino groups are characterized by H-1 NMR spectroscopy and matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. With the positively charged versions generated by removing the Boc groups, their ability to form spherical micelles that can be readily disassembled in the presence of glutathione (GSH) is demonstrated. The self-assembly behavior is monitored by scanning electron microscopy (SEM) and dynamic light scattering (DLS). The amphiphilic dendritic systems containing cleavable disulfide linkage serve as key building blocks for generating stimuli-responsive supramolecular architectures.
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