期刊
MACROMOLECULAR BIOSCIENCE
卷 21, 期 9, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202100129
关键词
(bio)polymers; biohybrid materials; hydrogels; nanoparticles; regenerative medicine; stimuli-responsive polymers; tissue engineering
资金
- National Science Foundation [CBET-1703402, DMR-1609544, DMR-2011824, DMR-2004890, CBET-2023668]
- National Institutes of Health [NIGMS 1-P30-BM110758, NCRR P20-RR017716, NIDCD RO1-DC011377A, S10-OD016361, NIGMS P20-GM103446]
Modulation of interactions between bioinspired designer molecules can be used for developing functional structures mimicking the complex organization of multicomponent assemblies in nature. Multistimuli-responsive molecules offer orthogonal tunability for versatile multifunctional platforms. Genetically engineered protein polymers with remarkable properties are discussed for applications in structured biomaterials.
Modulation of inter- and intramolecular interactions between bioinspired designer molecules can be harnessed for developing functional structures that mimic the complex hierarchical organization of multicomponent assemblies observed in nature. Furthermore, such multistimuli-responsive molecules offer orthogonal tunability for generating versatile multifunctional platforms via independent biochemical and biophysical cues. In this review, the remarkable physicochemical and mechanical properties of genetically engineered protein polymers derived from intrinsically disordered proteins, specifically elastin and resilin, are discussed. This review highlights emerging technologies which use them as building blocks in the fabrication of highly programmable structured biomaterials for applications in delivery of biotherapeutic cargo and regenerative medicine.
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