期刊
MACROMOLECULAR BIOSCIENCE
卷 21, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202100249
关键词
melanin; melanogenesis; melanosomes; polydopamine; polymersomes; tyrosinase
资金
- Swiss National Science Foundation
- University of Basel
- National Centre of Competence in Research - Molecular Systems Engineering
- Universitat Basel
By mimicking the confinement of natural melanin in melanosomes, melanosome mimics containing melanin/polydopamine within polymersomes are developed, showing long-term colloidal stability, cell-compatibility, and potential for cell photoprotection. This novel artificial melanogenesis is expected to inspire new applications of confined melanin/polydopamine biopolymers.
Melanin and polydopamine are potent biopolymers for the development of biomedical nanosystems. However, applications of melanin or polydopamine-based nanoparticles are limited by drawbacks related to a compromised colloidal stability over long time periods and associated cytotoxicity. To overcome these hurdles, a novel strategy is proposed that mimics the confinement of natural melanin in melanosomes. Melanosome mimics are developed by co-encapsulating the melanin/polydopamine precursors L-DOPA/dopamine with melanogenic enzyme Tyrosinase within polymersomes. The conditions of polymersome formation are optimized to obtain melanin/polydopamine polymerization within the cavity of the polymersomes. Similar to native melanosomes, polymersomes containing melanin/polydopamine show long-term colloidal stability, cell-compatibility, and potential for cell photoprotection. This novel kind of artificial melanogenesis is expected to inspire new applications of the confined melanin/polydopamine biopolymers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据