期刊
LWT-FOOD SCIENCE AND TECHNOLOGY
卷 144, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.lwt.2021.111253
关键词
Mixed oil; Emulsion; Stability; Digestion; Nobiletin bioavailability
资金
- National Natural Science Foundation of China [32072181, 31901681, 31901656]
- Open Project Program of Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, China
- CHENGUANG Biotech Group Co., Ltd. China
- Hunan FRUITOPS Co., Ltd., China
The study found that using corn oil-bergamot oil emulsions can increase the bioavailability of Nobiletin, with the 1:3 triacylglycerol-bergamot oil ratio being the most stable and the highest bioavailability observed in the 3:1 corn oil: bergamot oil emulsion.
Nobiletin is a citrus flavonoid with poor water solubility, which limits its application. To investigate the effects of emulsions on the bioavailability of nobiletin, long-chain triglycerides (LCT, i.e., corn oil) and medium-chain triglycerides (MCT) were used in combination with bergamot oil at different mixing ratios (i.e., 1:0, 3:1, 1:1, 1:3, and 0:1) as the oil phase to produce nobiletin-encapsulating emulsions by high-pressure homogenization. The emulsion stability, digestion fate, and bioavailability of nobiletin were systematically investigated. The results showed that triacylglycerol-bergamot oil at the ratio of 1:3 was the most stable. The hydrolysis rate of triacylglycerol-bergamot oil emulsions increased with increasing triacylglycerol: bergamot oil ratio. The total bioavailability of nobiletin in corn oil-bergamot oil emulsions was higher than that of pure bergamot oil and MCT-bergamot oil emulsions during in vitro digestion, due to the higher hydrolysis rate of corn oil-bergamot oil and greater solubilization capacity of micelles formed by bile salts and long-chain fatty acids (LCFAs) from corn oil. Nobiletin bioavailability was highest in the 3:1 corn oil: bergamot oil emulsion. This simulated digestion study may be useful for designing emulsion-based delivery systems to control the bioavailability of hydrophobic nutrients.
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