期刊
LUPUS
卷 30, 期 10, 页码 1617-1630出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/09612033211031008
关键词
Systemic lupus erythematosus; cognition; health-related quality of life; quality of life; health status; social role participation
类别
资金
- CRA (CIORA)-Arthritis Society Clinician Investigator Award
- Department of Medicine University of Toronto
- Canadian Institutes of Health Research
- Physicians' Services Incorporated Foundation
- Rocca Family
- Kaiser Family
- Arthritis Society
This study aimed to synthesize and critically appraise the quantitative literature on the relationship of cognitive impairment (CI) to health-related quality of life (HRQoL) and social role participation in individuals with Systemic Lupus Erythematosus (SLE). The findings suggest a negative relationship between CI and HRQoL as well as social role participation in SLE patients, highlighting the need for further research to clarify this relationship.
Introduction At least 38% of patients with Systemic Lupus Erythematosus (SLE) experience cognitive impairment (CI). Patients report CI impacts their health-related quality of life (HRQoL) and social role participation. Objectives To synthesize and critically appraise the quantitative literature on the relationship of CI to HRQoL and social role participation in individuals with SLE. Methods Six electronic databases were searched in December 2018 and June 2020 by an information specialist. Two reviewers independently completed all screening phases and data extraction; a third reviewer resolved disagreements. The Mixed Methods Appraisal Tool was used to critically appraise the quality of included studies. Data has been synthesized and analyzed descriptively to present evidence on the relationship of CI to HRQoL and social role participation. Results A total of 7182 references were identified and screened, with 14 articles included. Four of the included articles investigated the relationship between CI and HRQoL and all identified a negative relationship. Ten of the 14 studies investigated CI and social role participation, eight identified a negative relationship. There was heterogeneity of measures used between studies to examine CI, HRQoL, and social role participation. As such, results were interpreted descriptively and could not be pooled for meta-analysis. Conclusion The presence of CI is negatively related to HRQoL and social role participation in patients with SLE. Healthcare professionals should be aware of this relationship so that it can be addressed in clinical practice. Further research, using consistent methods of quantifying CI, HRQoL and social role participation, is needed to enable data pooling.
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