4.5 Article

KEAP1/NRF2 (NFE2L2) mutations in NSCLC-Fuel for a superresistant phenotype?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Clinical Implications of KEAP1-NFE2L2 Mutations in NSCLC

Jessica A. Hellyer et al.

Summary: Mutations in the KEAP1-NFE2L2 pathway are common in NSCLC and associated with enhanced tumor growth and aggressiveness, as well as resistance to cancer-directed therapies. The role of immunotherapy in this patient population is less clear, with conflicting studies on the efficacy of immune checkpoint inhibitors in KEAP1-NFE2L2-mutant NSCLC.

JOURNAL OF THORACIC ONCOLOGY (2021)

Article Oncology

PDL1 high expression without TP53, KEAP1 and EPHA5 mutations could better predict survival for patients with NSCLC receiving atezolizumab

Haiyong Wang et al.

Summary: This study found that white patients are more likely to have high PDL1 expression, different high frequency gene mutations can distinguish between patients with high and negative PDL1 expressions, and NSCLC patients receiving atezolizumab treatment with KEAP1, TP53, and EPHA5 gene mutations may have worse survival outcomes.

LUNG CANCER (2021)

Article Neurosciences

Divulging the Intricacies of Crosstalk Between NF-Kb and Nrf2-Keap1 Pathway in Neurological Complications of COVID-19

Ranjana Bhandari et al.

Summary: The severity of COVID-19 infection is increasing, with both respiratory and involvement in other organ systems documented. NF-kappa B and Nrf2 pathways play important roles in immune injury, neuro-invasion, and neuroinflammation, potentially serving as therapeutic targets.

MOLECULAR NEUROBIOLOGY (2021)

Article Oncology

Survival analysis for non-squamous NSCLC patients harbored STK11 or KEAP1 mutation receiving atezolizumab

Xiaoling Shang et al.

Summary: Non-squamous non-small cell lung cancer patients with STK11/KEAP1 mutations may not benefit more from both atezolizumab and docetaxel compared to wild type. However, patients with KEAP1 mutations alone and without STK11 mutations may have a better response to atezolizumab than docetaxel.

LUNG CANCER (2021)

Article Biochemistry & Molecular Biology

Beyond repression of Nrf2: An update on Keap1

Aleksandra Kopacz et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Cell & Tissue Engineering

Keap1-Nrf2 signaling pathway in angiogenesis and vascular diseases

Zi Guo et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2020)

Review Biochemistry & Molecular Biology

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Liam Baird et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Letter Oncology

KEAP1-NFE2L2-Mutant NSCLC and Immune Checkpoint Inhibitors: A Large Database Analysis

Chenyue Zhang et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

Review Pharmacology & Pharmacy

Can Activation of NRF2 Be a Strategy COVID-19?

Antonio Cuadrado et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Review Biochemistry & Molecular Biology

Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs

Pelin Telkoparan-Akillilar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

Nrf2 in cancers: A double-edged sword

Shijia Wu et al.

CANCER MEDICINE (2019)

Review Cell Biology

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

Natalia Robledinos-Anton et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Pharmacology & Pharmacy

Targeting the cell signaling pathway Keap1-Nrf2 as a therapeutic strategy for adenocarcinomas of the lung

Bo Zhang et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Review Oncology

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

Yunseo Woo et al.

JOURNAL OF ONCOLOGY (2019)

Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

Review Chemistry, Medicinal

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

Matej Sova et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

Review Biochemistry & Molecular Biology

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

Andrew N. Blackford et al.

MOLECULAR CELL (2017)

Article Biochemistry & Molecular Biology

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

Rodrigo Romero et al.

NATURE MEDICINE (2017)

Article Oncology

The KeAP1-NRF2 System in Cancer

Keiko Taguchi et al.

FRONTIERS IN ONCOLOGY (2017)

Review Biochemistry & Molecular Biology

Oxidative Stress

Helmut Sies et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 86 (2017)

Article Biochemistry & Molecular Biology

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

Anju Singh et al.

ACS CHEMICAL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System

Marcus Cebula et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

Article Biochemistry & Molecular Biology

Novel Roles of c-Met in the Survival of Renal Cancer Cells through the Regulation of HO-1 and PD-L1 Expression

Murugabaskar Balan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Cell Biology

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

Tongde Wu et al.

GENES & DEVELOPMENT (2014)

Article Biochemistry & Molecular Biology

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

Yoshinobu Ichimura et al.

MOLECULAR CELL (2013)

Review Biotechnology & Applied Microbiology

Modulation of oxidative stress as an anticancer strategy

Chiara Gorrini et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Multidisciplinary Sciences

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

Liam Baird et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

J. Ross Chapman et al.

MOLECULAR CELL (2012)

Article Multidisciplinary Sciences

Comprehensive genomic characterization of squamous cell lung cancers

Peter S. Hammerman et al.

NATURE (2012)

Review Pharmacology & Pharmacy

Heme Oxygenase-1 in Tumor Biology and Therapy

Halina Was et al.

CURRENT DRUG TARGETS (2010)

Review Biotechnology & Applied Microbiology

Neurodegenerative diseases and oxidative stress

KJ Barnham et al.

NATURE REVIEWS DRUG DISCOVERY (2004)