期刊
LUNG CANCER
卷 159, 期 -, 页码 45-55出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2021.06.024
关键词
Advanced NSCLC; [18F]-FDG PET; CT; Inflammatory prognostic biomarkers; Immunotherapy; Chemotherapy; Spleen glucose metabolism
The study revealed that high dNLR, high SII, and high SLR were independent prognostic factors in NSCLC patients treated with immunotherapy, while high BLR and high dNLR were associated with shorter progression-free survival and overall survival in patients treated with chemotherapy. BLR showed moderate correlations with most blood-based inflammatory indices, while SLR was only associated with CRP levels.
Objectives: We aimed to compare the prognostic value of inflammatory biomarkers extracted from pretreatment peripheral blood and [18F]-FDG PET for estimating outcomes in non-small cell lung cancer (NSCLC) patients treated with first-line immunotherapy (IT) or chemotherapy (CT). Materials and methods: In this retrospective multicenter study, we evaluated 111 patients with advanced NSCLC who underwent baseline [18F]-FDG PET/CT before IT or CT between 2016 and 2019. Several blood inflammatory indices were evaluated: derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP) and systemic immune-inflammation index (SII). FDG-PET inflammatory parameters were extracted from lymphoid tissues (BLR and SLR: bone marrow or spleen-to-Liver SUVmax ratios). Association with survival and relationships between parameters were evaluated using Cox prediction models and Spearman's correlation respectively. Results: Overall, 90 patients were included (IT:CT) (51:39pts). Median PFS was 8.6:6.6 months and median OS was not reached:21.2 months. In the IT cohort, high dNLR ( 3), high SII (>1,270) and high SLR (0.77) were independent statistically significant prognostic factors for one-year progression-free survival (1y-PFS) and twoyear overall survival (2y-OS) on multivariable analysis. In the CT cohort, high BLR (>0.80) and high dNLR (>3) were associated with shorter 1y-PFS (HR 2.2, 95% CI 1.0-4.9) and 2y-OS (HR 3.4, 95CI 1.1-10.3) respectively, on multivariable analysis. Finally, BLR significantly but moderately correlated with most blood-based inflammatory indices (CRP, PLR and SII) while SLR was only associated with CRP (p < 0.01 for all).
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