期刊
LUNG
卷 199, 期 4, 页码 403-407出版社
SPRINGER
DOI: 10.1007/s00408-021-00454-6
关键词
Lung cancer; Radiotherapy; Cardiorespiratory fitness; N-terminal pro-brain natriuretic peptide
资金
- Virginia Commonwealth University Massey Cancer Center Pilot Project Grant [P30CA016059K]
- National Center for Clinical and Translational Research Clinical and Translational Science Award [UL1TR002649]
Cardiorespiratory fitness is a strong predictor of cardiovascular health and overall mortality. Patients with lung cancer receiving radiotherapy may experience reduced CRF, with diastolic dysfunction and NTproBNP levels inversely correlated with peak VO2. NTproBNP is the strongest independent variable associated with peak VO2 in this population, indicating its significance in predicting CRF.
Cardiorespiratory fitness (CRF) is a robust and independent predictor of cardiovascular health and overall mortality. Patients with lung cancer often have chronic lung disease, contributing to impaired CRF. Radiation to the heart during lung cancer treatment may further reduce CRF. The determinants of CRF in this population are not well understood. We prospectively evaluated 12 patients with lung cancer without known cardiovascular disease with reduced lung function receiving curative intent thoracic radiotherapy to determine whether cardiac diastolic function, as assessed by Doppler echocardiography and N-terminal pro-brain natriuretic peptide (NTproBNP) levels, correlate with CRF measured by peak oxygen consumption (VO2). Doppler-derived measures of diastolic function and serum NTproBNP levels inversely correlated with peak VO2. In a multivariate regression model, NTproBNP was the strongest independent variable associated with peak VO2. These results suggest that diastolic dysfunction further contributes to reduced CRF in patients with lung cancer who have received radiotherapy.
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