☆ 4.5 Editorial Material

Biomarkers of Operational Tolerance After Liver Transplantation: Are We There Yet?

LIVER TRANSPLANTATION (2022)

Activated CD4+ T Cells and Highly Differentiated Alloreactive CD4+ T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients

Aafke A. Duizendstra et al.

Summary: Circulating hyperresponsive highly differentiated alloreactive CD4+ T cells and circulating activated T helper cells can differentiate tolerant liver transplantation recipients from a larger group of LT recipients.

LIVER TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management

Sandy Feng et al.

Summary: The study found that 37.5% of stable long-term pediatric liver transplant recipients were operationally tolerant, with rejection occurring in those who did not achieve operational tolerance after immunosuppression withdrawal. Liver histology did not deteriorate over the four-year period for both tolerant and nontolerant subjects, indicating the potential benefits of immunosuppression minimization.

HEPATOLOGY (2021)

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Article Surgery