Effect of statins on post-contrast acute kidney injury: a multicenter retrospective observational study

BackgroundPost-contrast acute kidney injury (PC-AKI) is a severe complication of coronary angiography (CAG) and percutaneous coronary intervention (PCI). Currently, the effect of statins on PC-AKI and its mechanism remains unclear.MethodsThis multicenter retrospective observational study included 4386 patients who underwent CAG or PCI from December 2006 to December 2019 in Sir Run Run Shaw Hospital and its medical consortium hospitals. Serum creatinine pre- or post-procedure within 72h after PCI was recorded. Multivariate logical regression was used to explore whether preoperative use of statins was protective from PC-AKI. The path analysis model was then utilized to look for the mediation factors of statins.ResultsFour thousand three hundred eighty-six patients were enrolled totally. The median age of the study population was 68years old, 17.9% with PC-AKI, and 83.3% on preoperative statins therapy. The incidence of PC-AKI was significantly lower in group of patients on statins therapy. Multivariate regression indicated that preoperative statins therapy was significantly associated with lower percentage of elevated creatinine (beta: -0.118, P<0.001) and less PC-AKI (OR: 0.575, P<0.001). In the preoperative statins therapy group, no statistically significant difference was detected between the atorvastatin and rosuvastatin groups (OR: 1.052, P=0.558). Pathway model analysis indicated a direct protective effect of preoperative statins therapy on PC-AKI (P<0.001), but not through its lipid-lowering effect (P=0.277) nor anti-inflammatory effect (P=0.596). Furthermore, it was found that low-density lipoprotein cholesterol (LDL-C)C-reactive protein (CRP) mediated the relationship between preoperative statins therapy and PC-AKI (P=0.007). However, this only explained less than 1% of the preoperative protective effects of statins on PC-AKI.ConclusionPreoperative statins therapy is an independent protective factor of PC-AKI, regardless of its type. This protective effect is not achieved by lipid-lowering effect or anti-inflammatory effect. These findings underscore the potential use of statins in preventing PC-AKI among those at risk.

Automated summary

The study indicates that preoperative statins therapy is associated with a lower risk of post-contrast acute kidney injury (PC-AKI) following coronary angiography and intervention, with the protective effect independent of lipid-lowering or anti-inflammatory effects. Low-density lipoprotein cholesterol (LDL-C) and C-reactive protein (CRP) were found to mediate the relationship between preoperative statins therapy and PC-AKI, explaining less than 1% of the protective effects.