期刊
LIPIDS IN HEALTH AND DISEASE
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12944-021-01517-6
关键词
Triglycerides; Pancreatitis; Fibrates; Secondary hypertriglyceridemia
资金
- ICES - Ontario Ministry of Health and Long-Term Care (MOHLTC)
- Academic Medical Organization of Southwestern Ontario
- Schulich School of Medicine and Dentistry, Western University
- Lawson Health Research Institute
- Jacob J. Wolfe Distinguished Medical Research Chair
- Edith Schulich Vinet Research Chair in Human Genetics
- Martha G. Blackburn Chair in Cardiovascular Research
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Ontario [G-18-0022147]
The incidence of severe and very severe hypertriglyceridemia in Canadian adults is 1 in 400 and 1 in 2500, respectively. Males, individuals with diabetes, obesity, and alcohol abuse are at highest risk for very severe hypertriglyceridemia. Increased surveillance is recommended for these high-risk groups.
Background The incidence of severe (S-HTG) and very severe hypertriglyceridemia (VS-HTG) among Canadians is unknown. This study aimed to determine the incidence, characteristics, predictors and care patterns for individuals with VS-HTG. Methods Using linked administrative healthcare databases, a population-based cohort study of Ontario adults was conducted to determine incidence of new onset S-HTG (serum triglycerides (TG) > 10-20 mmol/L) and VS-HTG (TG > 20 mmol/L) between 2010 and 2015. Socio-demographic and clinical characteristics of those with VS-HTG were compared to those who had no measured TG value > 3 mmol/L. Univariable and multivariable logistic regression were used to determine predictors for VS-HTG. Healthcare patterns were evaluated for 2 years following first incidence of TG > 20 mmol/L. Results Incidence of S-HTG and VS-HTG in Ontario was 0.16 and 0.027% among 10,766,770 adults >= 18 years and 0.25 and 0.041% among 7,040,865 adults with at least one measured TG, respectively. Predictors of VS-HTG included younger age [odds ratios (OR) 0.64/decade, 95% confidence intervals (CI) 0.62-0.66], male sex (OR 3.83; 95% CI 3.5-4.1), diabetes (OR 5.38; 95% CI 4.93-5.88), hypertension (OR 1.69; 95% CI 1.54-1.86), chronic liver disease (OR 1.71; 95% CI 1.48-1.97), alcohol abuse (OR 2.47; 95% CI 1.90-3.19), obesity (OR 1.49; 95% CI 1.13-1.98), and chronic kidney disease (OR 1.39; 95% CI 1.19-1.63). Conclusion The 5-year incidence of S-HTG and VS-HTG in Canadian adults was 1 in 400 and 1 in 2500, respectively. Males, those with diabetes, obese individuals and those with alcohol abuse are at highest risk for VS-HTG and may benefit from increased surveillance.
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