4.7 Article

4-Phenylselanyl-7-chloroquinoline attenuates hepatic injury triggered by neonatal exposure to monosodium glutamate in rats

期刊

LIFE SCIENCES
卷 280, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.119751

关键词

Selenium; Quinoline; Hypothalamic obesity; Hepatic damage; Thiobarbituric acid reactive species

资金

  1. UFPel
  2. CNPq [UNIVERSAL 408874/2016-3, 429859/2018-0]
  3. FAPERGS [PRONEM 16/2551-0000240-1, PRONU-PEQ 16/2551-0000526-5, PqG 17/2551-0001013-2, PqG 19/2551-0001745-6, PRONUPEQ 16/2551-0000526-5]
  4. Coordenacao de Aperfeicoamento de Pessoal de Nivel superior Brasil (CAPES) [001]

向作者/读者索取更多资源

The study investigated the protective effects of 4-phenylselenyl-7-chloroquinoline (4-PSQ) treatment on liver damage induced by monosodium glutamate (MSG) administration in neonatal rats. Results showed that 4-PSQ treatment reversed the liver damage caused by MSG, reduced plasma lactate levels in obese rats, and improved histological alterations in the liver.
Aims: Obesity is associated with a spectrum of hepatic abnormalities that can be experimentally induced by injections of monosodium glutamate (MSG) in neonatal rodents. We investigated the protective actions of the repeated therapy with 4-phenylselenyl-7-chloroquinoline (4-PSQ), a quinoline derivative containing selenium, on damage to the liver triggered by early postnatal administration of MSG in male Wistar rats. Main methods: Neonatal rats received MSG (4 g/kg, subcutaneous route) or saline (1 ml/kg) from 5 to 14 postnatal day (PND) to induce obesity with consequent damages in the liver. 4-PSQ treatment (5 mg/kg) or canola oil (1 ml/kg) was administered from 60 to 76 PND by the intragastric route. On 76 PND, animals were anesthetized for blood and liver collection. Plasma markers of hepatic function, hepatic lipoperoxidation levels and histology analysis of liver tissue were assessed. Key findings: Our data revealed that treatment with 4-PSQ reverted the increase in plasma transaminases activities observed in MSG rats. Treatment with 4-PSQ reduced plasma lactate levels in obese rats. In the liver, MSG elevated the content of lipoperoxidation which was reverted by 4-PSQ administrations. Lastly, 4-PSQ therapy attenuated the histological alterations induced by MSG. Significance: Together, the results indicate a hepatoprotective action of repeated treatment with 4-PSQ in obese rats.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据