期刊
LIFE SCIENCES
卷 276, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.119436
关键词
Rutin; Liquid crystalline nanoparticles; Lung cancer; Migration; Proliferation
资金
- International Medical University (IMU), Malaysia [BP I-01-2019(36)]
- Prevent Cancer Foundation (PCF)
- International Association for the Study of Lung Cancer (IASLC)
- Graduate School of Health
- University of Technology Sydney International Research Training Program Scholarship (IRTP)
- Cancer Council of NSW, Australia
This study explored the anti-cancer activity of Rutin-loaded liquid crystalline nanoparticles (LCNs) in non-small cell lung cancer cell line, showing promising anti-proliferative and anti-migratory activities, induction of apoptosis, and inhibition of colony formation. These findings provide important insights for further mechanistic studies of Rutin-LCNs as a potential therapeutic option for NSCLC.
Non-small cell lung cancer (NSCLC) is one of the major causes of cancer-related mortality globally. Despite the availability of therapeutic options, the improvement in patient survival is yet to be achieved. Recent advances in natural product (e.g., Rutin) research, therapeutic nanotechnology and especially the combination of both could aid in achieving significant improvements in the treatment or management of NSCLC. In this study, we explore the anti-cancer activity of Rutin-loaded liquid crystalline nanoparticles (LCNs) in an in vitro model where we have employed the A549 human lung epithelial carcinoma cell line. The anti-proliferative activity was determined by MTT and Trypan blue assays, whereas, the anti-migratory activity was evaluated by the scratch wound healing assay and a modified Boyden chamber assay. We also evaluated the anti-apoptotic activity by Annexin VFITC staining, and the colony formation activity was studied using crystal violet staining. Here, we report that Rutin-LCNs showed promising anti-proliferative and anti-migratory activities. Furthermore, Rutin-LCNs also induced apoptosis in the A549 cells and inhibited colony formation. The findings warrant further detailed and indepth anti-cancer mechanistic studies of Rutin-LCNs with a focus towards a potential therapeutic option for NSCLC. LCNs may help to enhance the solubility of Rutin used in the treatment of lung cancer and hence enhance the anticancer effect of Rutin.
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