4.7 Review

Current challenges and unmet medical needs in myelodysplastic syndromes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification-an approach to classification of patients with t-MDS

A. Kuendgen et al.

Summary: The study shows that therapy-related myelodysplastic syndromes (t-MDS) are as heterogeneous as primary MDS, and require the same careful differentiation regarding risk. Despite less favorable clinical outcomes in t-MDS subsets compared to primary MDS, classification and prognostic scoring effectively separated t-MDS patients into different risk groups.

LEUKEMIA (2021)

Review Hematology

Germline mutations in MDS/AML predisposition disorders

Lucy A. Godley

Summary: This review highlights the importance of recognizing hereditary hematopoietic malignancies in patient management and health surveillance strategies for relatives. It identifies current barriers to diagnosis and management, and suggests the need to overcome obstacles such as clinical testing difficulties, insurance coverage, and access to experts in the field. It also points out the importance of new research in improving treatment and maintaining excellent health for patients with predisposition genes.

CURRENT OPINION IN HEMATOLOGY (2021)

Article Oncology

Imetelstat Achieves Meaningful and Durable Transfusion Independence in High Transfusion-Burden Patients With Lower-Risk Myelodysplastic Syndromes in a Phase II Study

David P. Steensma et al.

Summary: Imetelstat treatment shows a meaningful and durable transfusion independence rate in heavily transfused LR-MDS patients, reducing malignant clone count and demonstrating disease modification activity. The most common adverse events are reversible cytopenias.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Eprenetapopt (APR-246) and Azacitidine in TP53-Mutant Myelodysplastic Syndromes

David A. Sallman et al.

Summary: The combination treatment with eprenetapopt and azacitidine is well-tolerated and results in high rates of clinical response and molecular remissions in patients with TP53-mutant MDS and oligoblastic AML.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Hematology

How we manage adults with myelodysplastic syndrome

Pierre Fenaux et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

Article Medicine, General & Internal

Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes

Pierre Fenaux et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Thrombosis and platelet dysfunction in myeloproliferative neoplasms

C. Mornet et al.

REVUE DE MEDECINE INTERNE (2020)

Review Hematology

Treatment of MDS

Uwe Platzbecker

Review Hematology

Novel therapies in low- and high-risk myelodysplastic syndrome

Ulrich Germing et al.

EXPERT REVIEW OF HEMATOLOGY (2019)

Meeting Abstract Hematology

CPX-351 As First Intensive Therapy for Elderly Patients with AML

Ellen K. Ritchie et al.

Review Hematology

Management of myelodysplastic syndromes after failure of response to hypomethylating agents

Angela Gil-Perez et al.

THERAPEUTIC ADVANCES IN HEMATOLOGY (2019)

Article Cell Biology

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

Luis A. Carvajal et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Oncology

Myelodysplastic syndromes current treatment algorithm 2018

David P. Steensma

BLOOD CANCER JOURNAL (2018)

Article Hematology

Myelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and management

Guillermo Montalban-Bravo et al.

AMERICAN JOURNAL OF HEMATOLOGY (2018)

Review Oncology

Clinical Implications of Genetic Mutations in Myelodysplastic Syndrome

James A. Kennedy et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Review Medicine, General & Internal

Technical Advances in the Measurement of Residual Disease in Acute Myeloid Leukemia

Gregory W. Roloff et al.

JOURNAL OF CLINICAL MEDICINE (2017)

Article Education, Scientific Disciplines

Uncoding the genetic heterogeneity of myelodysplastic syndrome

R. Coleman Lindsley

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2017)

Article Education, Scientific Disciplines

Current treatment algorithm for the management of lower-risk MDS

Aristoteles Giagounidis

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2017)

Review Hematology

Myelodysplastic syndromes: Contemporary review and how we treat

Naseema Gangat et al.

AMERICAN JOURNAL OF HEMATOLOGY (2016)

Article Hematology

Time-dependent changes in mortality and transformation risk in MDS

Michael Pfeilstoecker et al.

Review Biochemistry & Molecular Biology

Hereditary Predispositions to Myelodysplastic Syndrome

Sarah A. Bannon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Hematology

FLT3 mutations in myelodysplastic syndrome and chronic myelomonocytic leukemia

Naval Daver et al.

AMERICAN JOURNAL OF HEMATOLOGY (2013)

Article Medicine, General & Internal

Clinical Presentation, Diagnosis, and Prognosis of Myelodysplastic Syndromes

James M. Foran et al.

AMERICAN JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Clinical Effect of Point Mutations in Myelodysplastic Syndromes

Rafael Bejar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Oncology

Hematopoietic Growth Factors in Myelodysplastic Syndromes

David P. Steensma

SEMINARS IN ONCOLOGY (2011)

Article Hematology

Quality of life measurement in patients with transfusion-dependent myelodysplastic syndromes

AJG Jansen et al.

BRITISH JOURNAL OF HAEMATOLOGY (2003)