期刊
LANGMUIR
卷 37, 期 27, 页码 8064-8072出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.0c03578
关键词
-
资金
- National Natural Science Foundation of China [HSD17B13]
- [:81900516]
This study developed a multifunctional nanoprobe with excellent therapeutic outcomes and tumor-targeting characteristics, demonstrating its potential in the treatment of tumors.
Numerous researchers have committed to the development of combined therapy strategies for tumors, since their use in the treatment of tumors has more ideal therapeutic outcomes. In the study, we designed and prepared gold nanostars with CD147 modified on the surface and then efficiently loaded a photosensitive drug IR820 to construct a multifunctional nanoprobe. Due to the protection effect of gold, the nanoprobe has oxygen/heat energy generation capability and can also efficiently deliver the loaded drugs inside the tumor cells. Moreover, the nanoprobe has excellent photothermal/photodynamic therapeutic outcomes. The observation by photoacoustic real-time imaging validated the outstanding tumor-targeting characteristics of our nanoprobe. Finally, in the in vivo treatment experiment, the nanoprobe achieved ideal tumor-suppressive effects after the photothermal/photodynamic therapy. In summary, the findings of this experiment are useful in the development of new combined tumor therapy strategies based on nanomaterials.
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