期刊
LANGENBECKS ARCHIVES OF SURGERY
卷 406, 期 8, 页码 2807-2815出版社
SPRINGER
DOI: 10.1007/s00423-021-02323-5
关键词
Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy; HIPEC; Peritoneal surface malignancy; Pelvic exenteration
类别
Pelvic exenteration combined with CRS and HIPEC for PSM in a tertiary referral centre is feasible and safe, with no significant difference in perioperative major morbidity and mortality compared to PE alone. The majority of patients were female with colorectal cancer being the predominant pathology, and complete resection was achieved in all patients.
Purpose Pelvic exenteration (PE) for locally advanced pelvic malignancy is well established, though high rates of morbidity and mortality exist. Such a complication profile has often deterred the surgical community from offering exenteration in combination with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). We aimed to evaluate the perioperative outcomes following pelvic exenteration when combined with CRS and HIPEC for peritoneal surface malignancy (PSM) in a tertiary referral centre. Methods A review of a prospectively maintained PSM database from June 2015 to December 2020 at a tertiary referral institution was performed. Patients who underwent CRS, PE, and HIPEC were matched with patients who underwent PE alone. Primary endpoints were perioperative morbidity and mortality. Results From June 2015 to December 2020, 20 patients required PE as part of their CRS and HIPEC for PSM. The majority of patients were female (n = 16, 80%) with a median age of 52 (range 21-70). Colorectal cancer was the predominant pathology (n = 12, 60%). Median PCI was 11.5 (range 3-39). CC0 and R0 resections were achieved in all patients. CRS, PE, and HIPEC and PE-alone groups were well matched for clinicopathological variables. There was no difference in perioperative major morbidity (HIPEC: 30% vs PE: 15% p = 0.256) and mortality (HIPEC: 0 vs PE: 5% p = 0.311) between groups. Median follow-up was 17.5 months (range 7-68). Eight patients (40%) died from disease-related issues during the study period. Conclusion An aggressive surgical strategy with complete resection is feasible and safe in select patients with complex PSM involving the pelvis.
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