期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 98, 期 -, 页码 218-230出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2015.12.031
关键词
Skeletal muscle loss; MuRF-1; MAFbx; Ubiquitin-proteasome system
资金
- Rappaport Institute
- Krol Foundation of Barnegat N.J.
- Myers-JDC Brookdale Institute of Gerontology and Human Development
- ESHEL - the Association for Planning and Development of Services for the Aged in Israel
The ubiquitin-proteasome system (UPS) is the main regulatory mechanism of protein degradation in skeletal muscle. The ubiquitin-ligase enzymes (E3s) have a central role in determining the selectivity and specificity of the UPS. Since their identification in 2001, the muscle specific E3s, muscle RING finger-1 (MuRF-1) and muscle atrophy F-box (MAFbx), have been shown to be implicated in the regulation of skeletal muscle atrophy in various pathological and physiological conditions. This review aims to explore the involvement of MuRF-1 and MAFbx in catabolism of skeletal muscle during various pathologies, such as cancer cachexia, sarcopenia of aging, chronic kidney disease (CKD), diabetes, and chronic obstructive pulmonary disease (COPD). In addition, the effects of various lifestyle and modifiable factors (e.g. nutrition, exercise, cigarette smoking, and alcohol) on MuRF-1 and MAFbx regulation will be discussed. Finally, evidence of potential strategies to protect against skeletal muscle wasting through inhibition of MuRF-1 and MAFbx expression will be explored. (C) 2015 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据