4.4 Article

Hepatic lead and copper concentrations in dogs with chronic hepatitis and their relationship with hematology, serum biochemistry, and histopathology

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JOURNAL OF VETERINARY INTERNAL MEDICINE
卷 35, 期 4, 页码 1773-1779

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WILEY
DOI: 10.1111/jvim.16149

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biochemistry; canine; heavy metals; hematology; histopathology; liver

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This study evaluated the levels of lead ([Pb]) in the livers of dogs with chronic hepatitis (CH), and found a correlation between [Pb] and copper ([Cu]), as well as blood cell changes. Further research is needed to better understand the clinical role of hepatic lead in dogs with abnormal hepatic copper levels.
Background Although the influence of copper ([Cu]) on chronic hepatitis (CH) has been widely studied in dogs, little information is available about the accumulation of other metals. Hypothesis/Objectives We assessed the concentration of lead ([Pb]) in the livers of dogs with CH with or without abnormal hepatic [Cu] to establish if any association existed between [Pb] and either hematologic or biochemical variables, fibrosis, necrosis and inflammation of the liver on histology. Animals Thirty-four dogs with CH that had hepatic [Cu] and [Pb] determined. Methods Retrospective review of medical records of dogs with CH and hepatic [Cu] and [Pb]. Chronic hepatitis was defined using current American College of Veterinary Internal Medicine consensus statement guidelines. Hepatic [Cu] and [Pb] were determined using square wave anodic stripping voltammetry. Dogs were divided into 2 groups based on [Cu]: <400 ppm (LoCu) and >= 400 ppm (HiCu). Results The median [Cu] and [Pb] were 357 ppm (range, 100-7743 ppm) and 58.7 (range, 6.89-224.4 ppm), respectively. Nineteen dogs had LoCu and 15 dogs had HiCu. Median [Pb] was significantly higher in HiCu compared to LoCu dogs (P < .001). Hepatic [Pb] and [Cu] were significantly correlated (rho = 0.7; P < .001). Dogs with microcytosis had higher [Pb] than did dogs with normal red cell volume (P = .02). Hepatic [Pb] was not correlated with either necroinflammatory or fibrosis scores. Conclusions and Clinical Importance Although additional studies are needed to better understand the clinical role of hepatic [Pb], dogs with abnormal hepatic [Cu] may also have higher hepatic [Pb]. In addition, in dogs with high hepatic [Pb], microcytosis may be present.

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