4.6 Article

Statin Use and Lower Urinary Tract Symptoms Incidence and Progression in Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial

期刊

JOURNAL OF UROLOGY
卷 207, 期 2, 页码 418-423

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JU.0000000000002199

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prostatic; hyperplasia; lower urinary tract symptoms; hydroxymethylglutaryl-CoA reductase inhibitors

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This study analyzed the association between statin use and the incidence of LUTS in asymptomatic men, as well as the progression of LUTS in symptomatic men. The results showed no significant relationship between statin use and either LUTS incidence or progression. Therefore, statins do not appear to play a role in the prevention or management of LUTS.
Purpose: Benign prostatic hyperplasia (BPH) is a common disease often manifested by lower urinary tract symptoms (LUTS). We previously found statins were associated with modest attenuations in prostate growth over time in REDUCE. We tested whether statins were associated with LUTS incidence in asymptomatic men and LUTS progression in symptomatic men. Materials and Methods: We performed a post-hoc analysis of REDUCE in 3,060 asymptomatic men with baseline International Prostate Symptom Score (IPSS) <8 and in 2,198 symptomatic men with baseline IPSS >= 8 not taking alpha-blockers or 5 alpha-reductase inhibitors. We used multivariable Cox regression models to assess associations between statin use at baseline and LUTS incidence and progression. Among asymptomatic men, incident LUTS was defined as the first reported medical or surgical treatment for BPH or sustained clinically significant LUTS (2 reports of IPSS >14). Among symptomatic men, LUTS progression was defined as IPSS increase >= 4 points from baseline, any surgical procedure for BPH, or initiation of a BPH drug. Results: Among asymptomatic and symptomatic men, 550 (18%) and 392 (18%) used statins at baseline, respectively. On multivariable analysis, statin use was not associated with LUTS incidence (HR 1.05; 95% CI 0.78-1.41, p=0.74) in asymptomatic men, or with LUTS progression (HR 1.13; 95% CI 0.96-1.33, p=0.15) in symptomatic men. Similar results were seen in the dutasteride and placebo arms when stratified by treatment assignment. Conclusions: In REDUCE, statin use was not associated with either incident LUTS in asymptomatic men or LUTS progression in symptomatic men. These data do not support a role for statins in LUTS prevention or management.

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