4.7 Article

Chronotype: what role in the context of gastroenteropancreatic neuroendocrine tumors?

期刊

JOURNAL OF TRANSLATIONAL MEDICINE
卷 19, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12967-021-03010-1

关键词

Chronotype; Gastroenteropancreatic tumors (GEP-NET); Metabolic syndrome (MetS); Tumor aggressiveness; Diet; Nutrition; Nutritionist

向作者/读者索取更多资源

Patients with GEP-NET tend to have lower chronotype scores and more commonly display evening chronotypes compared to healthy subjects. Morning chronotype patients show better anthropometric measurements and MetS percentages. Patients with metastasis, G2 grading, and progressive disease tend to have lower chronotype scores.
Background Chronotype is defined as a trait determining the subject circadian preference in behavioral and biological rhythms relative to external light-dark cycle. Although individual differences in chronotype have been associated with an increased risk of developing some types of cancer, no studies have been carried out in gastroenteropancreatic neuroendocrine tumors (GEP-NET). Materials We investigate the differences in chronotype between 109 GEP-NET and 109 healthy subjects, gender-, age-, and BMI-matched; and its correlation with tumor aggressiveness. Results GEP-NET patients have a lower chronotype score (p = 0.035) and a higher percentage of evening chronotype (p = 0.003) than controls. GEP-NET patients with morning chronotype had lower BMI, waist circumference, and higher percentage of MetS (p < 0.001) than evening type. Interestingly, considering the clinical pathological characteristics, patients with the presence of metastasis, grading G2, and in progressive disease presented the lower chronotype score (p = 0.004, p < 0.001, and p = 0.002; respectively) compared to other categories. Chronotype score was negatively associated with anthropometric measurements, metabolic profile, percentage of MetS, and Ki67 index (p < 0.001 for all). Conclusions GEP-NET patients have an unhealthy metabolic profile and present more commonly an evening chronotype. These results support the importance of including the assessment of chronotype in an adjunctive tool for the prevention of metabolic alterations and tumor aggressiveness of GEP-NET.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据