期刊
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
卷 123, 期 -, 页码 47-58出版社
ELSEVIER
DOI: 10.1016/j.jtice.2021.05.024
关键词
Dielectric barrier discharge (DBD); Direct surface modification; Dual-responsive; Drug delivery; Mesoporous silica nanoparticles; Rice husk
资金
- Iran National Science Foundation [97014149]
- Sahand University of Technology
This paper investigates the uniformly surface modification of mesoporous silica nanoparticles using DBD plasma, characterizing the nanoparticles' structure and properties through different methods, exploring the release of the model drug Dox on nanocarriers, and studying the impact of modified nanocarriers on MCF-7 cells.
This paper deals with uniformly surface modification of mesoporous silica nanoparticles by applying dielectric barrier discharge (DBD) plasma as an energy-efficient and green approach. First, the mesoporous silica nanoparticles were synthesized from rice husk (RMSN-D) as an economic and biocompatible natural source. The surface modification stage by DBD plasma was performed in two methods: i) Direct mode and ii) Direct hybrid mode. The structure and physicochemical properties of the nanoparticles were characterized by XRD, FT-IR, Fe-SEM/EDS, TEM, EDS, BET, and H-NMR techniques. Doxorubicin (Dox) was exploited as a model drug, and in-vitro Dox release was investigated. The biocompatibility of nanocarriers was accepted by MTT test on HFF-2 cell line as a normal modal cell. For the advanced cellular study, apoptosis of the MCF-7 cell line treated with Dox-loaded nanocarriers was investigated by flow cytometric analysis and morphological study by fluorescent microscopy. The results showed that Dox-loaded RMSN-D modified by direct hybrid mode induced a high level of apoptosis in the MCF-7 cells. (c) 2021 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
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