4.4 Review

Determining PD-L1 Status in Patients With Triple-Negative Breast Cancer: Lessons Learned From IMpassion130

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Summary: In this multicentre study, PD-L1-IC-positivity for SP142, 22C3 and 28-8 was found to be reproducible and analytically concordant in TNBC, suggesting analytical interchangeability. However, SP263 showed significantly higher PD-L1-IC-positivity, warranting further investigation into its relevance. Inter-reader agreement was moderate-to-strong for each assay, while inter-assay agreement varied from poor to strong.

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