Clinical outcomes of older adults listed for heart transplantation in the United States

Objective To examine if older age (>70 years) should be a relative contraindication for heart transplantation, we evaluated the characteristics and outcomes of patients with age >= 70 years listed for heart transplantation; and whether post-transplantation survival was inferior to younger counterparts. Design Retrospective cohort analysis. Setting The scientific registry of transplant recipients (SRTR). Participants Adults (>= 18 years) listed for heart transplantation in the SRTR between 2000 and 2018. Interventions Heart transplantation. Measurements Characteristics and outcomes were compared for adults >= 70 years and The study included 57,285 patients (age range 18-79 years) listed for heart transplantation; 1203 (2.1%) age >= 70 years. Of these, 37,135 patients underwent heart transplantation; 806 (2.2%) were age >= 70 years. Yearly listing of those age >= 70 years has consistently increased from 2.5% (n = 30) in 2000 to 11% (n = 132) in 2017 (p < 0.01). As compared with the age <70 years group, those >= 70 years had a similar risk of death while waiting (sub-hazard ratio [SHR] 0.86, 95% confidence interval [HR] 0.68-1.08; p = 0.19) but were more likely to be transplanted (SHR 1.36, 95% CI 1.26-1.48; p < 0.01). Among the older patients, the overall post-transplant 1- and 5-year mortality rate was 10.4% and 19.2%, respectively. Older recipients had lower unadjusted survival compared with younger recipients (log-rank p = 0.03). However, after adjustment for relevant covariates, there was no significant difference in 5-year mortality between both groups (HR 1.06, 95% CI 0.91-1.254; p = 0.43). Conclusions Post-transplant survival up to 5 years among patients of age >= 70 years was similar to that of younger recipients. Older patients who received heart transplantation appear to have lower risk features but receive hearts from higher risk donors. Chronologic age alone should not constitute a contraindication for heart transplantation, although careful patient selection criteria should be applied.

Automated summary

The study found that post-transplant survival up to 5 years among patients aged >= 70 years was similar to that of younger recipients, although older recipients received hearts from higher risk donors. Therefore, chronological age alone should not constitute a contraindication for heart transplantation, although careful patient selection criteria should be applied.