期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 143, 期 36, 页码 14451-14457出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c07190
关键词
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资金
- National Nature Science Foundation of China [91956202, 21790330, 21821002]
- Science and Technology Commission of Shanghai Municipality [20JC1417000, 21520780100, 19590750400]
- strategic Priority Research Program [XDB20000000]
- Key Research Program of Frontier Science [QYZDJSSW-SLH055]
- International Partnership Program of the Chinese Academy of Sciences [121731KYSB20190016]
- Research Grants Council of Hong Kong [HKUST 16300620]
The first enantioselective copper-catalyzed cyanation of propargylic C-H bonds via radical relay has been established using novel Box(OTMS) ligands, providing an efficient tool for constructing structurally diverse chiral allenyl nitriles with high yields and excellent enantioselectivities. The reaction features high functional group tolerance and mild conditions, and the chiral allene products can be easily converted to other chiral compounds via axis-to-center chirality transfer.
The first enantioselective copper-catalyzed cyanation of propargylic C-H bonds via radical relay was established using novel Box(OTMS) ligands, providing an efficient and straightforward tool for the construction of structurally diverse chiral allenyl nitriles in good yields with excellent enantioselectivities. This reaction features high functional group tolerance and mild conditions. In addition, the chiral allene products can be readily converted to other chiral compounds via axis-to-center chirality transfer.
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