期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 124, 期 8, 页码 1390-1401出版社
WILEY
DOI: 10.1002/jso.26667
关键词
healthcare disparities; neuroendocrine carcinoma; pancreas cancer
资金
- Joseph and Ann Matella Fund for Pancreatic Cancer Research
- National Cancer Institute [R01CA242003, U54CA233444]
- National Human Genome Research Institute [T32 HG008958]
This study suggests that unlike other malignancies, race/ethnicity does not affect survival differences in patients with PNETs. Instead, patients with lower socioeconomic status have worse survival outcomes.
Background and Objectives Pancreatic neuroendocrine tumors (PNETs) represent a rare form of pancreatic cancer. Racial/ethnic disparities have been documented in pancreatic ductal adenocarcinoma, but health disparities have not been well described in patients with PNETs. Methods A retrospective review of patients with PNETs in the National Cancer Database was performed for 2004-2014. Approximately 16 605 patients with PNETs and available vital status were identified. Survival was compared by race/ethnicity and socioeconomic status using Kaplan-Meier methods and Cox regression. Results There were no significant differences in survival between Non-Hispanic, White; Hispanic, White; or Non-Hispanic, Black patients on univariate analysis. Kaplan-Meier analysis showed that patients from communities with lower median household income and education level had worse survival (p < 0.001). Patients age less than 65 without insurance, similarly, had worse survival (p < 0.001). Multivariable modeling found no association between race/ethnicity and risk of mortality (p = 0.37). Lower median household income and lower education level were associated with increased mortality (p < 0.001). Conclusions Unlike most other malignancies, race/ethnicity is not associated with survival differences in patients with PNETs. Patients with lower socioeconomic status had worse survival. The presence of identifiable health disparities in patients with PNETs represents a target for intervention and opportunity to improve survival in patients with this malignancy.
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