4.5 Article

Determination of major radionuclidic impurities in K99TcO4 pharmaceutical raw material

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出版社

SPRINGER
DOI: 10.1007/s10967-021-07902-w

关键词

Radionuclidic impurity; Tc-99 pharmaceutical; Actinides; Lanthanide nuclides; Rapid radioanalytical method

资金

  1. Ministry of Science and Technology of China [2015FY110800]
  2. National Natural Science Foundation of China [11605206, 12005197]

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A rapid analytical method for sequential separation and determination of alpha- and beta-emitting radionuclidic impurities in Tc-99 radiopharmaceutical raw material was presented. The method involves consecutive HTiO co-precipitation steps and sequential chromatographic method to effectively separate and purify the radionuclides. Method evaluation using spiked (KTcO4)-Tc-99 solutions demonstrated its capability to meet the analytical requirements for radionuclidic impurity evaluation of (KTcO4)-Tc-99 raw material.
A rapid analytical method for sequential separation and determination of the most significant alpha- and beta-emitting radionuclidic impurities in Tc-99 radiopharmaceutical raw material is presented. Successive HTiO co-precipitation steps were first conducted for effective removal of Tc-99 to avoid its spectral interference on the determination of beta-emitting nuclides by liquid scintillation counting. A sequential chromatographic method was applied for simultaneous separation and purification of actinide and lanthanide isotopes. A series of (KTcO4)-Tc-99 solution spiked with known quantities of Pu-238, Pu-239, Pu-241, Np-237, Am-241, Cm-244 and Pm-147 were analyzed for method evaluation, demonstrating that the method would meet the analytical requirements for radionuclidic impurity evaluation of (KTcO4)-Tc-99 raw material.

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