期刊
JOURNAL OF PSYCHOSOMATIC RESEARCH
卷 147, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychores.2021.110532
关键词
PROMIS; Depression; Measures; Screening; Psychometrics; PHQ-9
类别
资金
- National Institute of Arthritis and Musculoskeletal Disorders R01 award [R01 AR064081]
- Department of Veterans Affairs Health Services Research and Development Merit Review awards [IIR 11-125, IIR 10-128]
- Damush VA HSRD QUERI Service Directed Project [SDP-10-379]
The study aimed to compare the diagnostic performance of PROMIS depression scales with the PHQ-9 in detecting major depression. The results showed that PROMIS scales of various lengths had similar diagnostic operating characteristics, with high sensitivity and specificity. The optimal screening cutpoints for PROMIS raw scores on 4-, 6-, and 8-item scales were identified, and the average sensitivity and specificity for major depression were comparable to the PHQ-9.
Objective: To determine the diagnostic operating characteristics of The Patient Reported Outcomes Measurement Information Systems (PROMIS) depression scales in screening for major depression. Methods: Interview data from patients enrolled in clinical trials involving patients with chronic pain (2 trials) or post-stroke (1 trial) were analyzed. This included baseline and follow-up interviews in 648 and 586 study patients, respectively. Patients completed PROMIS depression scales of varying lengths (4-item, 6-item, and two 8item scale versions) as well as the Patient Health Questionnaire 9-item (PHQ-9) depression scale. A Structured Clinical Interview for DSM Disorders (SCID) was administered to establish diagnoses of major depression and any depression. Sensitivity and specificity at various score cutpoints as well as area under the curve (AUC) were calculated. Results: PROMIS scales of varying lengths had similar diagnostic operating characteristics. The optimal screening cutpoint for PROMIS raw scores on the 4-, 6-, and 8-item scales was 8, 12, and 16, respectively, which corresponds to a PROMIS T-score of 55. The average sensitivity and specificity of the two PROMIS 8-item scales for major depression across the 3 trials using a T-score cutpoint >55 was 0.81 and 0.84, respectively. This was almost identical to 0.81 and 0.82 for the PHQ-9 at its standard cutpoint score > 10. The average AUC for major depression was identical (0.91) for the two PROMIS 8-item scales and PHQ-9, and also similar for any depression (0.87 to 0.89). Conclusion: PROMIS scales ranging from 4 to 8 items have strong operating characteristics comparable to the PHQ-9 in screening for depression. Trial registration: ClinicalTrials.gov ID: NCT01236521, NCT01583985, NCT01507688
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