期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 36, 期 1, 页码 74-84出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/02698811211026454
关键词
Functional magnetic resonance imaging; resting-state connectivity; psilocybin; psychedelic; executive control network
资金
- Innovation Fund Denmark [4108-00004B]
- Independent Research Fund Denmark [6110-00518B]
- Ester M. og Konrad Kristian Sigurdssons Dyrevaernsfond [850-22-55166-17-LNG]
- Rigshospitalet Research Council [R130-A5324]
- Lundbeck Foundation [R231-2016-3236]
- Marie-Curie-NEUROMODEL [746850]
- COMPASS Pathways Ltd.
- Marie Curie Actions (MSCA) [746850] Funding Source: Marie Curie Actions (MSCA)
This study evaluated the long-term effects of psilocybin on resting-state functional connectivity in healthy psychedelic-naive volunteers. The results showed that psilocybin decreased executive control network connectivity at 1 week, which predicted increased mindfulness at 3 months. This suggests that psilocybin may have lasting effects on brain connectivity and mindfulness.
Background: Psilocybin is a psychedelic drug that has shown lasting positive effects on clinical symptoms and self-reported well-being following a single dose. There has been little research into the long-term effects of psilocybin on brain connectivity in humans. Aim: Evaluate changes in resting-state functional connectivity (RSFC) at 1 week and 3 months after one psilocybin dose in 10 healthy psychedelic-naive volunteers and explore associations between change in RSFC and related measures. Methods: Participants received 0.2-0.3 mg/kg psilocybin in a controlled setting. Participants completed resting-state functional magnetic resonance imaging (fMRI) scans at baseline, 1-week and 3-month post-administration and [11C]Cimbi-36 PET scans at baseline and 1 week. We examined changes in within-network, between-network and region-to-region RSFC. We explored associations between changes in RSFC and psilocybin-induced phenomenology as well as changes in psychological measures and neocortex serotonin 2A receptor binding. Results: Psilocybin was well tolerated and produced positive changes in well-being. At 1 week only, executive control network (ECN) RSFC was significantly decreased (Cohen's d = -1.73, pFWE = 0.010). We observed no other significant changes in RSFC at 1 week or 3 months, nor changes in region-to-region RSFC. Exploratory analyses indicated that decreased ECN RSFC at 1 week predicted increased mindfulness at 3 months (r = -0.65). Conclusions: These findings in a small cohort indicate that psilocybin affects ECN function within the psychedelic 'afterglow' period. Our findings implicate ECN modulation as mediating psilocybin-induced, long-lasting increases in mindfulness. Although our findings implicate a neural pathway mediating lasting psilocybin effects, it is notable that changes in neuroimaging measures at 3 months, when personality changes are observed, remain to be identified.
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