期刊
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
卷 46, 期 4, 页码 E418-E426出版社
CMA-CANADIAN MEDICAL ASSOC
DOI: 10.1503/jpn.200176
关键词
-
资金
- German Research Foundation (DFG) [FOR2107 DA1151/5-1, DA1151/5-2, SFB-TRR58]
- Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster [Dan3/012/17, SEED 11/19]
- NIH/NIMH [U01 MH110008, R01 MH092301]
- NIH/MIMH [U01 MH111826]
- Lundbeck Foundation
This study showed that higher body mass index (BMI) was associated with a lower increase in subcortical grey matter volume following ECT. It also found significant negative associations between BMI and change in subcortical grey matter volume, with pronounced effects in specific brain regions. Additionally, BMI moderated the association between subcortical grey matter volume change and clinical response to ECT.
Background: Obesity is a frequent somatic comorbidity of major depression, and it has been associated with worse clinical outcomes and brain structural abnormalities. Converging evidence suggests that electroconvulsive therapy (ECT) induces both clinical improvements and increased subcortical grey matter volume in patients with depression. However, it remains unknown whether increased body weight modulates the clinical response and structural neuroplasticity that occur with ECT. Methods: To address this question, we conducted a longitudinal investigation of structural MRI data from the Global ECT-MRI Research Collaboration (GEMRIC) in 223 patients who were experiencing a major depressive episode (10 scanning sites). Structural MRI data were acquired before and after ECT, and we assessed change in subcortical grey matter volume using FreeSurfer and Quarc. Results: Higher body mass index (BMI) was associated with a significantly lower increase in subcortical grey matter volume following ECT. We observed significant negative associations between BMI and change in subcortical grey matter volume, with pronounced effects in the thalamus and putamen, where obese participants showed increases in grey matter volume that were 43.3% and 49.6%, respectively, of the increases found in participants with normal weight. As well, BMI significantly moderated the association between subcortical grey matter volume change and clinical response to ECT. We observed no significant association between BMI and clinical response to ECT. Limitations: Because only baseline BMI values were available, we were unable to study BMI changes during ECT and their potential association with clinical and grey matter volume change. Conclusion: Future studies should take into account the relevance of body weight as a modulator of structural neuroplasticity during ECT treatment and aim to further explore the functional relevance of this novel finding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据