Encoding of vestibular and optic flow cues to self-motion in the posterior superior temporal polysensory area

Key points Neurons in the posterior superior temporal polysensory area (STPp) showed significant directional selectivity in response to vestibular, optic flow and combined visual-vestibular stimuli. By comparison to the dorsal medial superior temporal area, the visual latency was slower in STPp but the vestibular latency was faster. Heading preferences under combined stimulation in STPp were usually dominated by visual signals. Cross-modal enhancement was observed in STPp when both vestibular and visual cues were presented together at their heading preferences. Human neuroimaging data implicated that the superior temporal polysensory area (STP) might be involved in vestibular-visual interaction during heading computations, but the heading selectivity has not been examined in the macaque. Here, we investigated the convergence of optic flow and vestibular signals in macaque STP by using a virtual-reality system and found that 6.3% of STP neurons showed multisensory responses, with visual and vestibular direction preferences either congruent or opposite in roughly equal proportion. The percentage of vestibular-tuned cells (18.3%) was much smaller than that of visual-tuned cells (30.4%) in STP. The vestibular tuning strength was usually weaker than the visual condition. The visual latency was significantly slower in STPp than in the dorsal medial superior temporal area (MSTd), but the vestibular latency was significantly faster than in MSTd. During the bimodal condition, STP cells' response was dominated by visual signals, with the visual heading preference not affected by the vestibular signals but the response amplitudes modulated by vestibular signals in a subadditive way.

Automated summary

The study revealed the convergence of optic flow and vestibular signals in macaque STP, with 6.3% of neurons showing multisensory responses. In STP, the percentage of vestibular-tuned cells (18.3%) was much smaller than that of visual-tuned cells (30.4%), indicating a dominance of visual signals.