期刊
JOURNAL OF PHYSIOLOGICAL SCIENCES
卷 71, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12576-021-00800-6
关键词
Astrocyte; Fluorocitrate; Spinal cord; Neurovascular coupling; Blood flow; Local field potential
类别
资金
- Natural Science and Engineering Research Council of Canada [06559, 05403]
- Fonds de recherche du Quebec en Sante (FRQS)
Inhibiting astrocyte metabolism alters spinal neurovascular coupling, affecting spinal cord imaging techniques.
Functional magnetic resonance imaging (fMRI) of the spinal cord relies on the integrity of neurovascular coupling (NVC) to infer neuronal activity from hemodynamic changes. Astrocytes are a key component of cerebral NVC, but their role in spinal NVC is unclear. The objective of this study was to examine whether inhibition of astrocyte metabolism by fluorocitrate alters spinal NVC. In 14 rats, local field potential (LFP) and spinal cord blood flow (SCBF) were recorded simultaneously in the lumbosacral enlargement during noxious stimulation of the sciatic nerve before and after a local administration of fluorocitrate (N = 7) or saline (N = 7). Fluorocitrate significantly reduced SCBF responses (p < 0.001) but not LFP amplitude (p = 0.22) compared with saline. Accordingly, NVC was altered by fluorocitrate compared with saline (p < 0.01). These results support the role of astrocytes in spinal NVC and have implications for spinal cord imaging with fMRI for conditions in which astrocyte metabolism may be altered.
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