Shape of Testosterone

We have successfully characterized the structure of testosterone, one of the essential steroids, through high-resolution rotational spectroscopy. A single conformer has been detected, and a total of 404 transitions have been fitted, allowing a precise determination of the rotational constants. It allowed us to unravel that the isolated structure of testosterone adopts an extended disposition. The results obtained in this work highlight how using laser ablation techniques in combination with Fourier transform microwave techniques allow the study of large biomolecules or common pharmaceuticals. It is an important step toward studying relevant biomolecules and developing new analytical techniques with unprecedented sensitivity and resolution.

Automated summary

The structure of testosterone was successfully characterized using high-resolution rotational spectroscopy, revealing an extended disposition in its isolated form. This study demonstrates the importance of combining laser ablation techniques with Fourier transform microwave techniques for studying large biomolecules and pharmaceuticals. It represents a significant step towards studying relevant biomolecules and developing new analytical techniques with unprecedented sensitivity and resolution.