Thoughts on the Protein's Native State

The presence of metamorphism in the protein's native state is not yet fully understood. To shed light on this issue, we present an assessment, in terms of the amide hydrogen exchange protection factor, that aims to determine the possible existence of structural fluctuations in the native-state consistent with both the upper-bound marginal stability of proteins and the presence of metamorphism. The preliminary results enable us to conclude that the native-state metamorphism is, indeed, more probable than previously thought.

Automated summary

By assessing the amide hydrogen exchange protection factor, it is concluded that structural fluctuations in the native state of proteins are consistent with metamorphism. Therefore, the presence of metamorphism in the native state is more probable than previously thought based on preliminary results.